by American Society of Hematology MAY 17, 2024 Metformin 500mg tablets. Credit: public domainPeople who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances. Metformin is a therapy used...
Researchers find that weight, smoking habits, and exercise may impact one’s likelihood of developing multiple myeloma Peer-Reviewed Publication AMERICAN SOCIETY OF HEMATOLOGY (WASHINGTON, January 12, 2024) – Individuals with obesity are more likely to have monoclonal gammopathy of undetermined significance (MGUS), a benign blood condition that often precedes multiple myeloma, according to new research published...
Seeking strategic partners for continued clinical development of PBCLN-010 with PBCLN-014, a lead investigational therapy comprising human milk sugars and gut bacteria found in nursing infants Business Announcement PROLACTA BIOSCIENCE DUARTE, Calif., Nov. 10, 2023 – In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient...
by American Society of Hematology Micrograph of a plasmacytoma, the histologic correlate of multiple myeloma. H&E stain. Credit: Wikipedia/CC BY-SA 3.0Patients with multiple myeloma treated with idecabtagene vicleucel, known as “ide-cel,” a chimeric antigen receptor (CAR) T-cell therapy, had no difference in overall survival outcomes regardless of race and ethnicity, according to a study published in...
by Jackie Maupin, Indiana University School of Medicine Credit: Unsplash/CC0 Public Domain Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that obesity was strongly associated with the condition. Their findings were recently published in the Journal of Clinical Investigation. CHIP...
by Walter and Eliza Hall Institute of Medical Research Hematological and iron markers are similar in PV patients with and without history of venesection. (A) Hematocrit (HCT); (B) red blood cell count (RBC); (C) ferritin; (D) transferrin saturation; (E) serum hepcidin; (F) serum ERFE, (G) hepcidin:ferritin ratio, (H) platelet count and (I) leukocyte count in...
by University of Tsukuba Credit: Kateryna Kon/Shutterstock Cells contain diverse populations of molecules called lipids, which are organic fatty compounds. Lipid metabolism, the synthesis and breakdown of these lipids, plays a key role in regulating the composition and functions of cells and cell membranes. An enzyme known as ELOVL6 elongates chains of fatty acids and is...
by NYU Langone Health Credit: Unsplash/CC0 Public Domain Severe inflammation weakens the body’s ability to kill cancerous blood cells in people with acute myeloid leukemia (AML), a new study shows. Experiments in human cells also revealed how increasing levels of inflammation, marked by an aggressive reaction of immune cells in the bone marrow, altered the makeup of immune B cells...
by Queen Mary, University of London Noncoding mutations impacting BCL genes. a, Genome view of BCL2 5′ UTR. The significantly mutated region is indicated by a black rectangle. Individual somatic mutations are shown in blue. b, Gene expression of BCL2 in TPM determined by RNA-seq in samples with BCL2 5′ UTR mutations versus WT. Black dots are...
T-cell acute lymphoblastic leukemia, or T-ALL, affects more than 6,000 Americans each year. Researchers characterized the thymocyte cells—an immune cell present in the thymus—while studying mice with T-ALL. They determined all of the rodent tumors originated from the same type of T cell that expresses a unique set of molecular markers. “Once we identified the cell in...
