by Rachel Tompa, Stanford University Medical Center Turning kinase inhibitors into activators of therapeutic genes. Credit: Science (2024). DOI: 10.1126/science.adl5361 Our bodies divest themselves of 60 billion cells every day through a natural process of cell culling and turnover called apoptosis. These cells—mainly blood and gut cells—are all replaced with new ones, but the way our bodies rid...
Tag: <span>Blood cancer</span>
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Medical breakthrough provides hope for early risk stratification of a deadly blood cancer
August 9, 2024 by Davide Montebruno, University of Manitoba Dr. Sabine Mai. Credit: University of ManitobaDr. Sabine Mai, Canada Research Chair in Genomic Instability and Nuclear Architecture of Cancer with the Rady Faculty of Health Sciences recently co-authored an article published in the American Journal of Hematology. The groundbreaking study shows early risk stratification of...
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Anti-diabetic treatment associated with reduced risk of developing blood cancer
by American Society of Hematology MAY 17, 2024 Metformin 500mg tablets. Credit: public domainPeople who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances. Metformin is a therapy used...
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Obesity linked to detection of blood cancer precursor
Researchers find that weight, smoking habits, and exercise may impact one’s likelihood of developing multiple myeloma Peer-Reviewed Publication AMERICAN SOCIETY OF HEMATOLOGY (WASHINGTON, January 12, 2024) – Individuals with obesity are more likely to have monoclonal gammopathy of undetermined significance (MGUS), a benign blood condition that often precedes multiple myeloma, according to new research published...
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Initial patient dosed in Phase 2a clinical trial evaluating first-in-class human milk-based therapy in patients undergoing stem cell transplantation for blood cancers
Seeking strategic partners for continued clinical development of PBCLN-010 with PBCLN-014, a lead investigational therapy comprising human milk sugars and gut bacteria found in nursing infants Business Announcement PROLACTA BIOSCIENCE DUARTE, Calif., Nov. 10, 2023 – In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient...
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CAR T-cell therapy effective in patients with blood cancer regardless of race: Study
by American Society of Hematology Micrograph of a plasmacytoma, the histologic correlate of multiple myeloma. H&E stain. Credit: Wikipedia/CC BY-SA 3.0Patients with multiple myeloma treated with idecabtagene vicleucel, known as “ide-cel,” a chimeric antigen receptor (CAR) T-cell therapy, had no difference in overall survival outcomes regardless of race and ethnicity, according to a study published in...
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Researchers find link between obesity and blood cancer
by Jackie Maupin, Indiana University School of Medicine Credit: Unsplash/CC0 Public Domain Indiana University School of Medicine researchers studying clonal hematopoiesis of indeterminate potential (CHIP), a blood condition that may increase the risk of blood cancer, discovered that obesity was strongly associated with the condition. Their findings were recently published in the Journal of Clinical Investigation. CHIP...
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Iron regulation offers new treatment hope for incurable blood cancer
by Walter and Eliza Hall Institute of Medical Research Hematological and iron markers are similar in PV patients with and without history of venesection. (A) Hematocrit (HCT); (B) red blood cell count (RBC); (C) ferritin; (D) transferrin saturation; (E) serum hepcidin; (F) serum ERFE, (G) hepcidin:ferritin ratio, (H) platelet count and (I) leukocyte count in...
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The role of lipids in blood cancer: New insights into uncharted territory
by University of Tsukuba Credit: Kateryna Kon/Shutterstock Cells contain diverse populations of molecules called lipids, which are organic fatty compounds. Lipid metabolism, the synthesis and breakdown of these lipids, plays a key role in regulating the composition and functions of cells and cell membranes. An enzyme known as ELOVL6 elongates chains of fatty acids and is...
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Inflammation levels tied to severity of blood cancer
by NYU Langone Health Credit: Unsplash/CC0 Public Domain Severe inflammation weakens the body’s ability to kill cancerous blood cells in people with acute myeloid leukemia (AML), a new study shows. Experiments in human cells also revealed how increasing levels of inflammation, marked by an aggressive reaction of immune cells in the bone marrow, altered the makeup of immune B cells...