Tag: <span>Blood cancer</span>

Home / Blood cancer
Inflammation levels tied to severity of blood cancer
Post

Inflammation levels tied to severity of blood cancer

by NYU Langone Health Credit: Unsplash/CC0 Public Domain Severe inflammation weakens the body’s ability to kill cancerous blood cells in people with acute myeloid leukemia (AML), a new study shows. Experiments in human cells also revealed how increasing levels of inflammation, marked by an aggressive reaction of immune cells in the bone marrow, altered the makeup of immune B cells...

Genetic research identifies new subgroups of blood cancer that can be used to predict likely clinical outcomes
Post

Genetic research identifies new subgroups of blood cancer that can be used to predict likely clinical outcomes

by Queen Mary, University of London Noncoding mutations impacting BCL genes. a, Genome view of BCL2 5′ UTR. The significantly mutated region is indicated by a black rectangle. Individual somatic mutations are shown in blue. b, Gene expression of BCL2 in TPM determined by RNA-seq in samples with BCL2 5′ UTR mutations versus WT. Black dots are...

Post

RARE THYMOCYTE CELLS CAN TURN INTO BLOOD CANCER

T-cell acute lymphoblastic leukemia, or T-ALL, affects more than 6,000 Americans each year. Researchers characterized the thymocyte cells—an immune cell present in the thymus—while studying mice with T-ALL. They determined all of the rodent tumors originated from the same type of T cell that expresses a unique set of molecular markers. “Once we identified the cell in...

Improving interferon therapy for blood cancers
Post

Improving interferon therapy for blood cancers

by Melissa Rohman, Northwestern University Credit: Pixabay/CC0 Public Domain [Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular type of blood cancer, according to findings published in Nature Communications. Targeting this pathway in combination with...

Lucky find could hold key to beating rare blood cancer
Post

Lucky find could hold key to beating rare blood cancer

by South Australian Health and Medical Research Institute (SAHMRI)  Graphical abstract. Credit: DOI: 10.15252/embr.202152904 Adelaide researchers have discovered a new method to treat the rare and crippling blood cancer, myelofibrosis, that could have the potential to greatly extend lifespan while also significantly improving quality of life. Myelofibrosis affects 1 in 100,000 Australians and while symptoms...

Blood cancer and arthritis patients taking Rituximab show impaired antibody response to COVID vaccine
Post

Blood cancer and arthritis patients taking Rituximab show impaired antibody response to COVID vaccine

by University of Birmingham Immune reconstitution following CD20 depletion and vaccine responsiveness. (A) Time between last administration of anti-CD20 B-cell-depleting treatment and vaccine administration (left panel—haemato-oncology patients [red], right panel—rheumatology patients [blue]). (B) Seropositivity following SARS-CoV-2 vaccination with respect to time from last administration of anti-CD20 B-cell depletion. (C) Association between the magnitude of antibody...

Scientists identify new types of a blood cancer and potential targeted treatments
Post

Scientists identify new types of a blood cancer and potential targeted treatments

by  The Mount Sinai Hospital Killer T cells surround a cancer cell. Credit: NIH Mount Sinai researchers have developed a new model that uses DNA and RNA sequencing data from hundreds of patients to identify specific genes and genetic alterations responsible for never-before-defined subtypes of a blood cancer called multiple myeloma. They also identified potential targeted...

Post

Poor immune response in many double- vaccinated blood cancer patients

More than half of double vaccinated blood cancer patients have been left with little protection against COVID-19, new research has found. Data from the SOAP-02 trial, published today in a letter to Cancer Cell, examines the level of immune protection following the delayed Pfizer vaccine boost in 159 participants, 128 of whom were cancer patients. Although...