LUND UNIVERSITY Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome patients, MDS. In a study published in the Molecular Cell journal, they explain what makes hematopoietic stem cells acquire malignant traits in cancer. RNA splicing is a major...
Tag: <span>blood stem cells</span>
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How a leukemia hijacks the genes needed by blood stem cells
by Gina Mantica, Children’s Hospital Boston Lynn Aureli hopes to inspire others in her new position as an oncology nurse at Dana-Farber Cancer Institute. Credit: Michael Goderre, Boston Children’s Hospital As a child, Lynn Aureli didn’t know that a particular genetic change contributed to her acute myeloid leukemia (AML)—an alteration that eventually would help explain...
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How blood stem cells maintain their lifelong potential for self-renewal
GERMAN CANCER RESEARCH CENTER (DEUTSCHES KREBSFORSCHUNGSZENTRUM, DKFZ) A characteristic feature of all stem cells is their ability to self-renew. But how is this potential maintained throughout life? Scientists at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine* (HI-STEM) have now discovered in mice that cells in...
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A new strategy for making blood stem cells healthier
by Albert Einstein College of Medicine Credit: CC0 Public Domain The hematopoietic (blood-forming) stem cells (HSCs) residing in our bone marrow produce all of our blood cells, including key immune cells that protect us from bacteria and viruses. As we age, our HSCs become less efficient and less able to make healthy new blood cells. In...
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Mapping out the mystery of blood stem cells
by University Health Network Credit: CC0 Public Domain Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells. The finding, obtained from studying normal blood, can be...