Tag: <span>BMC Biotechnology.</span>

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Toxicity of dorsal root ganglia is widely associated with CNS AAV gene therapy
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Toxicity of dorsal root ganglia is widely associated with CNS AAV gene therapy

MARY ANN LIEBERT, INC./GENETIC ENGINEERING NEWS JOURNAL IN THE FIELD AND PROVIDES ALL-INCLUSIVE ACCESS TO THE CRITICAL PILLARS OF HUMAN GENE THERAPY: RESEARCH, METHODS, AND CLINICAL APPLICATIONS New Rochelle, NY, September 2, 2020—A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology. There were...

Syringe technology could enable injection of concentrated biologic drugs
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Syringe technology could enable injection of concentrated biologic drugs

Researchers have designed a simple, low-cost device for subcutaneous injection of viscous formulations. MIT researchers have developed a simple, low-cost technology to administer powerful drug formulations that are too viscous to be injected using conventional medical syringes. The technology, which is described in a paper published today in the journal Advanced Healthcare Materials, makes it...

568 genes identified with the potential to trigger cancer
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568 genes identified with the potential to trigger cancer

INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) ANALYSIS OF THE GENOMES OF 28,000 TUMORS FROM 66 TYPES OF CANCER. view more CREDIT: IRB BARCELONA Cancer is a group of diseases characterised by uncontrolled cell growth caused by mutations, and other alterations in the genome of cells. A tumour can present from hundreds to thousands of...

Designed bacteria produce coral-antibiotic
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Designed bacteria produce coral-antibiotic

Sustainable biotechnological production of a natural substance against tuberculosis TECHNICAL UNIVERSITY OF MUNICH (TUM) HORN CORALS OF THE SPECIES ANTILLOGORGIA ELISABETHAE PRODUCE ANTIBIOTIC NATURAL SUBSTANCES. A RESEARCH TEAM AT TUM HAS SUCCESSFULLY PRODUCED ONE OF THESE SUBSTANCES IN THE LABORATORY. view more CREDIT: (IMAGE: THOMAS BRÜCK / TUM) Thomas Brück saw the sea whip Antillogorgia...

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Stomach SIDT1 mediates dietary microRNA absorption: ending of the 10-year debate

NANJING UNIVERSITY SCHOOL OF LIFE SCIENCES In a new study published in Cell Research, Chen-Yu Zhang’s group at Nanjing University School of Life Sciences, China, reports that SIDT1 in the mammalian stomach mediates host uptake of dietary and orally administered microRNAs (miRNAs), thus exerting biological functions in the host. In previous studies, Chen-Yu Zhang’s group...

Fighting cancer with rejection-resistant, ‘off-the-shelf’ therapeutic T cells
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Fighting cancer with rejection-resistant, ‘off-the-shelf’ therapeutic T cells

by Ana María Rodríguez, Ph.D., Baylor College of Medicine Scanning electron microscopy image of a human lymphocyte. Credit: National Cancer Institute Personalized cancer treatments are no longer just options of the future. In the past few years, researchers have made significant progress in ‘teaching’ the body’s immune T cells to recognize and kill specific cancer...

Researchers study brain activity in stages of alertness at the neuronal level
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Researchers study brain activity in stages of alertness at the neuronal level

by Okinawa Institute of Science and Technology Visual information detected in the eye, is passed to the visual thalamus – a complex sub-cortical structure that regulates information transmission from the sensory organs to sensory areas of the cortex – and on to the primary visual cortex. Researchers know that layer 6, the deepest cortical layer,...

Swallowing this colonoscopy-like bacteria grabber could reveal secrets about your health
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Swallowing this colonoscopy-like bacteria grabber could reveal secrets about your health

ONCE SWALLOWED, THIS CAPSULE IS DESIGNED TO COLLECT BACTERIA THROUGHOUT THE GUT. A SCIENTIST UNSCREWS THE CAP TO RETRIEVE THE SAMPLE AFTER THE CAPSULE HAS LEFT THE DIGESTIVE SYSTEM. view more Your gut bacteria could say a lot about you, such as why you’re diabetic or how you respond to certain drugs. But scientists can...

NexStride Helps Overcome Freeze of Gait in Parkinson’s
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NexStride Helps Overcome Freeze of Gait in Parkinson’s

People with Parkinson’s disease and some other neurological disorders often suffer from a condition known as freezing of gait. For poorly understood reasons, initiating a step is often a challenge. Patients report a feeling of disassociation between one’s will to move and the legs not responding accordingly. This is both frustrating and can lead to...

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