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Enzyme inhibition promotes bone formation and curbs the development of bone metastases, study finds
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Enzyme inhibition promotes bone formation and curbs the development of bone metastases, study finds

by  German Cancer Research Center Negative regulation of bone formation by TAM receptor MERTK. a mRNA expression analysis of TAM receptor family Mertk, Tyro3, Axl, Gas6, and Pros1 in primary murine osteoblast cultures after 0, 7, 14, and 21 days (n = 3 biological replicates) (Mertk expression d0 vs. d7: p = 0.0002; d0 vs. d14: p = 0.0042; d0 vs. d21: p = 0.0172), (Tyro3 expression d0 vs. d7: p = 0.009; d0 vs. d14: p = 0.9604; d0 vs. d21: p = 0.2928), (Axl expression...

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Spherical biodegradable carriers support scalable and cost-effective stem cell expansion and bone formation

Stem cells (red) on polycaprolactone-based microcarriers.    Bone tissue engineering is theoretically now possible at a large scale. A*STAR researchers have developed small biodegradable and biocompatible supports that aid stem cell differentiation and multiplication as well as bone formation in living animal models. Mesenchymal stem cells self-renew and differentiate into fat, muscle, bone, and cartilage cells, which makes them...