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Transcription factor prevents bone frailty in chronic kidney disease
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Transcription factor prevents bone frailty in chronic kidney disease

by Melissa Rohman, Northwestern University Genetic overexpression of Hnf4α2 in osteoblasts prevents bone loss in mice with chronic kidney disease. Microtomography analysis of femur cortical bone at metaphysis and at midshaft in 20-week-old wild-type mice. Credit: Northwestern University Northwestern Medicine investigators have discovered that the overexpression of a transcription factor prevented bone loss in mouse models...