by Delthia Ricks , Medical Xpress Credit: CC0 Public DomainAlthough immunologists have developed a deep reservoir of knowledge illuminating how antibodies respond to vaccination against SARS-CoV-2, little is known about the elusive cells that produce infection-fighting antibodies. Although antibodies are among the first responders when infectious agents invade the body, they’re produced by mystifying cells...
by Anne Grimm, Leipzig University Credit: CC0 Public DomainWhen people develop myelodysplastic neoplasms (MDS), the healthy maturation of blood cells is impaired. Severe forms, known as higher-risk MDS, are characterized by rapid progression, severe symptoms and often a transition to acute leukemia. Patients for whom potentially curative or intensive treatments, such as stem cell transplantation or...
by Elisabeth Reitman, Yale University Atherogenesis is depicted in a young (a) or aged (b) host. Aged monocytes/macrophages have decreased levels of the epigenetic regulator TET2, leading to reduction of the 5-hydroxymethylcytosine (5hmC) mark on the Itgb3 promoter. The resulting low integrin β3 levels in aged monocytes/macrophages induces high TNFα levels, facilitating recruitment and expansion...
by Katherine Unger Baillie, University of Pennsylvania Inflammation in the gums can increase susceptibility to other forms of inflammation, such as arthritis, through changes to immune cell precursors in the bone marrow, according to new research led by Penn scientists and collaborators. Credit: Katie Vicari The immune system remembers. Often this memory, primed by past...
by Mary Ann Liebert, Inc Hematopoietic precursor cells: promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate. Credit: Bobjgalindo/Wikipedia A new study compares the regenerative potential of blood/bone marrow aspirate concentrates obtained from arterial blood, venous blood, and bone marrow aspirate. The study, conducted in rabbits, is...
by Massachusetts General Hospital Credit: CC0 Public Domain Hematopoietic stem cells (HSCs) have the capacity to both self-renew and differentiate into all mature blood cell types, making them promising treatments for a variety of diseases. However, the mechanisms involved in engraftment—when the cells start to grow and make healthy blood cells after being transplanted into...
by St. Jude Children’s Research Hospital Credit: CC0 Public Domain Scientists at St. Jude Children’s Research Hospital have developed the first GRP78 targeted chimeric antigen receptor (CAR) T cell. Their GRP78 CAR T cell successfully targeted and destroyed acute myelogenous leukemia (AML) cells in the lab. A paper on the work appeared today in Nature Communications....
Reviewed by Emily Henderson, B.Sc. Jul 5, 2021 While this isn’t the fountain of youth, scientists may have improved healing in our joints – even in areas that become weaker as we grow older. The meniscus is a durable, yet flexible tissue found in joints like our wrist and knees that helps them absorb shock...
by Study Finds HOUSTON — Injecting bone marrow into the brain could help stroke victims recover, suggests a new study. Results of a clinical trial provide evidence that treating severe stroke patients with an injection of bone marrow cells may lead to a reduction in brain injury. The breakthrough could help reduce the impact from severe...
ALPHAMED PRESS IMAGE: Autologous bone-marrow mononuclear cells were intravenously administered in patients with acute ischemic stroke as procedure outline in panel A. The non-treated patients were recruited separately. Both groups were imaged 3 time over year and neuroimaging biomarkers were developed. Integrity of the ipsilesional and contralesional cortical spinal tracts (CST) were evaluated via diffusion...
