By Dr. Chinta SidharthanReviewed by Benedette Cuffari, M.Sc.Nov 29 2024 Study links T-ALL tumor subpopulations to treatment failure, maps healthy pediatric blood development, and identifies a potential therapy targeting drug-resistant cells. Study: A multiomic atlas identifies a treatment-resistant, bone marrow progenitor-like cell population in T cell acute lymphoblastic leukemia. Image Credit: Matt_Images / Shutterstock.com In a recent study...
Tag: <span>Bone marrow</span>
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Bone marrow cancer drug shows success in treatment of rare blood disorder
September 18, 2024 NIH-supported clinical trial is the first positive trial for treatment of hereditary hemorrhagic telangiectasia. A clinical trial supported by the National Institutes of Health (NIH) was stopped early after researchers found sufficient evidence that a drug used to treat bone marrow cancer and Kaposi sarcoma is safe and effective in treating hereditary...
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New nanoparticle delivery method targets sickle cell mutations in bone marrow
JULY 19, 2024 by Johnny Moseman, Johns Hopkins University Discovery and development of BM-homing LNPs. a, Schematic of LNP preparation including covalent lipid species (covalent lipids and crosslinkers). b, Addition of a covalent lipid or crosslinker to the base-4-lipid LNP formulation leads to BM mRNA delivery and genome editing in a great breadth of unique...
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Elusive immune cells dwelling in ‘hidden niches’ of the bone marrow may be key to SARS-CoV-2 vaccination
by Delthia Ricks , Medical Xpress Credit: CC0 Public DomainAlthough immunologists have developed a deep reservoir of knowledge illuminating how antibodies respond to vaccination against SARS-CoV-2, little is known about the elusive cells that produce infection-fighting antibodies. Although antibodies are among the first responders when infectious agents invade the body, they’re produced by mystifying cells...
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Researching a new treatment option for severe blood disorders of the bone marrow
by Anne Grimm, Leipzig University Credit: CC0 Public DomainWhen people develop myelodysplastic neoplasms (MDS), the healthy maturation of blood cells is impaired. Severe forms, known as higher-risk MDS, are characterized by rapid progression, severe symptoms and often a transition to acute leukemia. Patients for whom potentially curative or intensive treatments, such as stem cell transplantation or...
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Study finds aging of bone marrow accelerates arterial plaque formation
by Elisabeth Reitman, Yale University Atherogenesis is depicted in a young (a) or aged (b) host. Aged monocytes/macrophages have decreased levels of the epigenetic regulator TET2, leading to reduction of the 5-hydroxymethylcytosine (5hmC) mark on the Itgb3 promoter. The resulting low integrin β3 levels in aged monocytes/macrophages induces high TNFα levels, facilitating recruitment and expansion...
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How one inflammatory disorder exacerbates another
by Katherine Unger Baillie, University of Pennsylvania Inflammation in the gums can increase susceptibility to other forms of inflammation, such as arthritis, through changes to immune cell precursors in the bone marrow, according to new research led by Penn scientists and collaborators. Credit: Katie Vicari The immune system remembers. Often this memory, primed by past...
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Researchers describe the regenerative potential of solid bone marrow aspirate concentrate
by Mary Ann Liebert, Inc Hematopoietic precursor cells: promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate. Credit: Bobjgalindo/Wikipedia A new study compares the regenerative potential of blood/bone marrow aspirate concentrates obtained from arterial blood, venous blood, and bone marrow aspirate. The study, conducted in rabbits, is...
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New research could help improve bone marrow and stem cell transplants for patients with blood-related diseases
by Massachusetts General Hospital Credit: CC0 Public Domain Hematopoietic stem cells (HSCs) have the capacity to both self-renew and differentiate into all mature blood cell types, making them promising treatments for a variety of diseases. However, the mechanisms involved in engraftment—when the cells start to grow and make healthy blood cells after being transplanted into...
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CAR T cells target acute myelogenous leukemia, spare bone marrow
by St. Jude Children’s Research Hospital Credit: CC0 Public Domain Scientists at St. Jude Children’s Research Hospital have developed the first GRP78 targeted chimeric antigen receptor (CAR) T cell. Their GRP78 CAR T cell successfully targeted and destroyed acute myelogenous leukemia (AML) cells in the lab. A paper on the work appeared today in Nature Communications....