by Melissa Pappas, University of Pennsylvania School of Engineering and Applied Science Credit: Unsplash/CC0 Public Domain Multiple myeloma is an incurable bone marrow cancer that kills over 100,000 people every year. Known for its quick and deadly spread, this disease is one of the most challenging to address. As these cancer cells move through different...
by University of Virginia Deletion of IL-1R1 preferentially inhibits Jak2V617F mutant hematopoietic stem/progenitor cells. a A scheme on competitive BM transplantation approach to assess the effects of IL-1R1 deletion on Jak2V617F mutant hematopoietic stem/progenitors is depicted. b Percentages of donor-derived (CD45.2+) total, myeloid cells (Gr1+), B cells (B220+), and T cells (TCRβ+) in peripheral blood were measured every 4...
by Susan Murphy, Mayo Clinic The transcriptome of ASXL1MT CMML is characterized by transcriptional up-regulation of key mitotic pathways and leukemogenic driver genes. Credit: Nature Communications (2022). DOI: 10.1038/s41467-022-29142-6 New research from Mayo Clinic’s Center for Individualized Medicine finds that patients with ASXL1-mutant chronic myelomonocytic leukemia—an uncommon type of cancer of the bone marrow—have distinctive epigenetic changes...
by Boston University School of Medicine Hematopoietic precursor cells: promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate. Credit: Bobjgalindo/Wikipedia Primary myelofibrosis (PMF), a relatively rare but painful type of bone marrow cancer, disrupts the body’s normal production of blood cells by causing extensive scarring in the bone...
