by Cincinnati Children’s Hospital Medical Center These maps pinpoint the location of blood progenitors and their differentiating offspring in the mouse bone marrow. This is the first study to image blood production at this level of detail, say experts at Cincinnati Children’s. Findings were published Feb 10, 2021, in Nature. Credit: Cincinnati Children’s Imagine a day when...
by Albert Einstein College of Medicine Credit: CC0 Public Domain The hematopoietic (blood-forming) stem cells (HSCs) residing in our bone marrow produce all of our blood cells, including key immune cells that protect us from bacteria and viruses. As we age, our HSCs become less efficient and less able to make healthy new blood cells. In...
UNIVERSITY OF ILLINOIS AT CHICAGO SINGLE CELLS ENCAPSULATED IN HYDROGEL WITH VARIED DEPOSITION USING A NEW TECHNIQUE DEVELOPED AT UIC. Researchers at the University of Illinois Chicago have developed a unique method for precisely controlling the deposition of hydrogel, which is made of water-soluble polymers commonly used to support cells in experiments or for therapeutic...
Once breast cancer spreads to bone, treatment becomes nearly impossible. Breast cancer cells can lie dormant in the bone, often undetectable and able to escape typical treatments. Unfortunately, these dormant cells can awaken at any time to generate tumors. All of this combined makes it difficult to understand how the cells proliferate and how to...
Human cells shed exosomes. These tiny extracellular, membrane-bound vesicles can carry cargo for cell-to-cell communication, ferrying diverse loads of proteins, lipids or nucleic acids. University of Alabama at Birmingham and Chinese researchers now report that exosomes are key to the SOS signal that the heart muscle sends out after a heart attack. After the heart attack, the exosomes in the bloodstream carry greatly increased amounts of heart-specific microRNAs—an observation seen in both mice...
Severe inflammation caused by a patient’s immune system can be deadly, but stem cells found in human fat could provide new ways to protect against this toxic reaction. Fat has a higher ratio of stem cells than other tissues such as bone marrow. Credit: Robert M. Hunt, licensed under CC BY 3.0 (image was cropped,...
CAR cells are specialized mesenchymal stem cells, which express the specific transcription factors, Ebf1/3, inhibiting osteoblast differentiation to remain undifferentiated, maintain marrow cavities, enhance CXCL12 and SCF expression, and create HSC niches. Hematopoietic stem cells (HSCs) are a class of stem cells located in bone marrow. HSCs give rise to every type of blood cell—from...
According to their website, Rexgenero is a “regenerative medicine company and developer of advanced cell-based therapeutics for the treatment of serious diseases that are poorly treated with existing therapies.” The head office of Rexgenero is in London, but their Research and Development laboratories are in Seville, Spain. They also have a United Kingdom office in Brighton, which...
Researchers have for the first time shown it may be possible to detect early – or pre-fibrotic – stages of myelofibrosis noninvasively with magnetic resonance imaging. The current standard method of diagnosing the rare bone marrow cancer is through tissue analysis of biopsy samples. Myelofibrosis is a rare, slowly evolving cancer where bone marrow becomes...
