CAR cells are specialized mesenchymal stem cells, which express the specific transcription factors, Ebf1/3, inhibiting osteoblast differentiation to remain undifferentiated, maintain marrow cavities, enhance CXCL12 and SCF expression, and create HSC niches. Hematopoietic stem cells (HSCs) are a class of stem cells located in bone marrow. HSCs give rise to every type of blood cell—from...
Tag: <span>Bone marrow</span>
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Rexgenero Treats Its First Patient In Phase III Clinical Trial of Bone Marrow-Based Critical Limb Ischemia Treatment
According to their website, Rexgenero is a “regenerative medicine company and developer of advanced cell-based therapeutics for the treatment of serious diseases that are poorly treated with existing therapies.” The head office of Rexgenero is in London, but their Research and Development laboratories are in Seville, Spain. They also have a United Kingdom office in Brighton, which...
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Bone marrow cancer: Noninvasive detection steps closer
Researchers have for the first time shown it may be possible to detect early – or pre-fibrotic – stages of myelofibrosis noninvasively with magnetic resonance imaging. The current standard method of diagnosing the rare bone marrow cancer is through tissue analysis of biopsy samples. Myelofibrosis is a rare, slowly evolving cancer where bone marrow becomes...