by Atrium Health Wake Forest Baptist Bolus administration of 2 mg/kg 3,4-DAP reverses clinical signs of botulism and prolongs survival. A Summary of experimental models. B Median ± interquartile ratio (IQR) toxic signs for rats given a single injection of vehicle (black) or 3,4-DAP (pink) at 28 h after challenge with 0.44 ng/kg BoNT/A (2.5 LD50 BoNT/A; n = 4 per group)....