Highlights • Oxytocin and arginine-vasopressin are similar in structure as are their receptors. • Oxytocin and arginine-vasopressin can activate each other’s receptors (i.e., cross-talk). • Receptor cross-talk can occur in the brain and the periphery. • Understanding receptor cross-talk will important for drug development. Abstract Oxytocin (OT) and arginine-vasopressin (AVP) act in the brain to regulate social cognition/social behavior and in the periphery...