by University College London Credit: Unsplash/CC0 Public Domain Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumor called a glioma. Previous studies have suggested a possible link between head injury and increased rates of brain...
by University of California, Los Angeles Single-cell sequencing reveals the diverse functional states of glioma cells post-radiation. a UMAP plot of cell clusters from control (0 Gy) and 2- and 7-days radiated (8 Gy) fractions. b Histogram shows the number of cells per cluster in each group. c Heatmap shows Louvain clustering of co-expressed gene network modules and EnrichR GO_terms associated with each...
Yale researchers have developed a new class of molecules targeting some deadliest brain cancers while sparing healthy tissue. The discovery, which combines innovative synthetic chemistry and cutting-edge mechanistic studies in molecular biology, offers a potentially powerful new approach to treating drug-resistant glioma tumors that form in the brain and spinal cord. A study describing the...
by Katie Marquedant, Massachusetts General Hospital Glioma of the left parietal lobe. CT scan with contrast enhancement. Credit: Mikhail Kalinin/CC BY-SA 3.0 Researchers at Massachusetts General Hospital (MGH) who previously developed a blood test for mutations in a gene linked to gliomas, the most common type of adult brain tumors, have now applied their technology to...
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: NANOSTRUCTURED LIPID CARRIERS CONTAINING DOCETAXEL AND FUNCTIONALIZED WITH BEVACIZUMAB MAGNIFIED 100,000 TIMES CREDIT: LEONARDO DI FILIPPO/UNESP A drug carrier able to reach the brain, bind to an aggressive type of tumor called glioblastoma multiforme, and release a chemotherapeutic agent has been tested for the...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN IMAGE: GLIOMA CELLS CREDIT: UNIVERSITY OF MICHIGAN ROGEL CANCER CENTER ANN ARBOR, Michigan — Scientists at the University of Michigan Rogel Cancer Center were optimistic when they identified a small molecule that blocked a key pathway in brain tumors. But there was a problem: How to get the inhibitor...
by Brigham and Women’s Hospital Encapsulated stem cells (green) tracking and killing GBM tumor cells (red). Credit: Shah lab (CSTI) Glioblastomas (GBMs) are highly aggressive cancerous tumors of the brain and spinal cord. Brain cancers like GBM are challenging to treat because many cancer therapeutics cannot pass through the blood-brain barrier, and more than 90...
By Mark Waghorn via SWNS Milk may hold the key to beating brain cancer, according to new research. It can deliver gene silencing drugs that shrink deadly tumors. The white stuff contains chemicals that can carry siRNA’s (small interfering RNAs) that prevent manufacture of proteins that fuel the growths. Currently, the dairy food’s nanoparticles are being cultured...
by University of California, San Francisco A microscope image of brain cancer cells, a glioma tumor type known as anaplastic astrocytoma. Credit: Wikimedia/ CC BY-SA 3.0 Patients diagnosed with a type of brain tumor survived for longer when they were treated aggressively with surgery, radiation and chemotherapy. But far from suggesting that more treatment always...
Every once in a while the thing you’re looking for can be found right under your nose. Or in your medicine cabinet. Pathologist Paul Mischel, MD, has spent years studying glioblastoma — a difficult to treat, often deadly brain cancer. Recently, he and postdoctoral scholar Junfeng Bi, Ph.D., made a surprising discovery — a common antidepressant,...
