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Researchers create ‘chameleon’ compound that targets drug-resistant brain cancers
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Researchers create ‘chameleon’ compound that targets drug-resistant brain cancers

JUNE 3, 2024 by Jim Shelton, Yale University Credit: Journal of the American Chemical Society (2024). DOI: 10.1021/jacs.3c06483In a new study, Yale researchers describe how a novel chemical compound attacks drug-resistant brain tumors without harming healthy surrounding tissue. The research, published in the Journal of the American Chemical Society, is a crucial step in the...

New mechanisms underlying tumor variety in brain cancers discovered
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New mechanisms underlying tumor variety in brain cancers discovered

MAY 20, 2024 by Melissa Rohman, Northwestern University High-grade meningiomas are distinguished by regionally distinct intratumor immune infiltration, MAPK signaling, PI3K-AKT signaling, and cell proliferation. Credit: Amy B. Heimberger, MD, Ph.D. Investigators have discovered new mechanisms underlying the diversity of characteristics within a single tumor, as well as treatment resistance, in the most common type...

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One in five brain cancers fueled by overactive mitochondria

COLUMBIA UNIVERSITY IRVING MEDICAL CENTER NEW YORK, NY (Jan. 11, 2021)–A new study has found that up to 20% of glioblastomas–an aggressive brain cancer–are fueled by overactive mitochondria and may be treatable with drugs currently in clinical trials. Mitochondria are responsible for creating the energy that fuels all cells. Though they are usually less efficient...