October 2, 2024 by The Spanish National Cancer Research Centre Cells around a brain metastasis in an animal model: several brain cells (astrocytes, white) surround an immune system cell (lymphocyte, green). Some of them have started to activate the factor (red) inducing molecule TIMP1, which will enable them to disable the action of the lymphocyte...
Tag: <span>brain metastasis</span>
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Mechanism facilitates brain metastasis from breast cancer and melanoma by inducing neuroinflammation
by Tel-Aviv University Brain metastatic burden and survival in mice injected with breast cancer cells. a. Experimental scheme analyzed in (b,c). b. Survival curve analysis of WT and Lcn2-/- mice injected intracardially with BT-EO771 cells, (WT n = 10, Lcn2-/- n = 9 mice) (Kaplan–Meier curve, log-rank test). c. Quantification of brain metastatic burden for mice in (a), quantified as %...
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AI better than human eye at predicting brain metastasis outcomes, find researchers
by York University Architecture of (a) vanilla 3D residual network (baseline), (b) the 3D residual network with CBAM attention, (c) the proposed self-attention-guided 3D residual network, (d) the residual block in 3D residual network, consisting of residual connections, (e) the CBAM attention block consisting of the channel and spatial attention modules, and (f) the self-attention...
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Warning: Popular Vitamin Supplement Causes Cancer Risk and Brain Metastasis
By UNIVERSITY OF MISSOURI-COLUMBIA NOVEMBER 12, 2022 New research finds that the popular dietary supplement nicotinamide riboside could increase the risk of serious disease, including developing cancer. University of Missouri researchers made the discovery while using bioluminescent imaging technology to study how nicotinamide riboside supplements work inside the body. Commercial dietary supplements like nicotinamide riboside (NR), a...
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Novel brain-permeable BRAF inhibitor shows promise in more effectively reaching and treating melanoma brain metastasis
VALL D’HEBRON INSTITUTE OF ONCOLOGY IMAGE: JOAN SEOANE, CO-DIRECTOR OF PRECLINICAL AND TRANSLATIONAL RESEARCH AT THE VALL D’HEBRON INSTITUTE OF ONCOLOGY (VHIO). CREDIT: VALL D’HEBRON INSTITUTE OF ONCOLOGY (VHIO). Published in Cancer Research, findings reveal the potent and prolonged antitumor activity of C1a in patient-derived preclinical models of mutant-BRAF-driven melanoma brain metastases, even upon relapse on...