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Mechanism underlying Alzheimer-like damage in the brain of patients with Down Syndrome

TEMPLE UNIVERSITY HEALTH SYSTEM (Philadelphia, PA) – Life expectancy for individuals with Down syndrome has grown in recent decades, thanks in large part to progress in patient care and treatment. But with survival into the fifth and sixth decades of life now possible, increasing numbers of these individuals are affected by conditions linked to aging,...

Study unveils new protein-related changes in the brain of patients with Alzheimer’s disease
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Study unveils new protein-related changes in the brain of patients with Alzheimer’s disease

by Ingrid Fadelli, Medical Xpress TMT AD Protein Co-Expression Network. (A-C) 516 dorsolateral prefrontal cortex (DLPFC) tissues from the Religious Orders Study and Memory and Aging Project (ROSMAP, n=84 control, 148 AsymAD, 108 AD) and Banner Sun Health Brain Bank (Banner, n=26 control, 58 AsymAD, 92 AD) were analyzed by tandem mass tag mass spectrometry...