by Olivia Dimmer, Northwestern University Multiplex immunofluorescence staining and imaging using the COMET system platform on a human meningioma patient sample, showing SSTR2+ tumor cells (in red), expressing the hedgehog pathway activation marker sonic hedgehog (SHH, in cyan blue). Credit: Hinda NajemScientists have uncovered a genetic explanation for one subset of common brain tumors, according to...
by University of Turku Fluorine-18-labelled folate PET/CT 3D fusion image of a rat subject with a glioma visible in the central region of the brain. Credit: Maxwell Miner Folate-based radiopharmaceuticals can be used in positron emission tomography (PET) imaging to detect folate receptors in brain tumors. The discovery of folate receptors and their exploitation potential with...
by University of Gothenburg The researchers’ molecule Z4P inhibits one of the mechanisms that regulate protein production in a cancer cell. This inhibition causes the cancer cell to die. Three pictures show the spread of the tumor after 20 days of treatment on mice. Control: Untreated tumor. TMZ: Follow-up treatment solely with chemotherapy. Combo: Combination treatment with...
by Swedish Research Council Graphical abstract. Credit: Cancer Cell (2023). DOI: 10.1016/j.ccell.2023.04.010 Researchers from Uppsala University have developed a method that helps immune cells exit from blood vessels into a tumor to kill cancer cells. The goal is to improve treatment of aggressive brain tumors. The study has been published in the journal Cancer Cell. Glioblastoma is an aggressive brain tumor that...
APRIL 24, 2023 by Study Finds BALTIMORE — A “miracle” gel that cures brain tumors in mice could offer new hope for human cancer patients, a new study reveals. Researchers at John Hopkins University say the medication delivered by the substance stops 100 percent of an aggressive form of brain cancer within mice. The “striking” result provides new...
NAGOYA UNIVERSITY IMAGE: MICROSCOPIC IMAGE OF NANOWIRES CREDIT: DR TAKAO YASUI Researchers at Nagoya University in Japan have used a new device to identify a key membrane protein in urine that indicates whether the patient has a brain tumor. Their protein could be used to detect brain cancer, avoiding the need for invasive tests, and increasing...
by Katie Marquedant, Massachusetts General Hospital Correlation analysis between SCD expression and sensitivity to YTX-7739. (A) Immunoblot analysis (left) of SCD expression in YTX-7739-sensitive and -resistant GSCs lines. Also shown (right) is the correlation analysis between the EC50 of YTX-7739 and SCD expression in all 12 GSCs lines. Western-blot bands of SCD normalized to GAPDH were...
By BRIGHAM AND WOMEN’S HOSPITAL JANUARY 5, 2023 Researchers at Brigham and Women’s Hospital have found a way to use cancer cells to fight cancer. In a study published in Science Translational Medicine, the team led by Khalid Shah demonstrated that their cell therapy could eliminate established tumors and create long-term immunity in an advanced mouse model of glioblastoma,...
Despite significant advances, mortality from brain tumors remains high with five-year survival rates of 36%, according to the National Cancer Institute. More accurate diagnoses might improve the situation, but tissue biopsies are invasive and can miss important information about a tumor’s make-up. Imaging-based methods, meanwhile, do not offer sufficient sensitivity and resolution. Now, researchers reporting in ACS Nano have...
by American Chemical Society Graphical abstract. Credit: ACS Nano (2022). DOI: 10.1021/acsnano.2c04187 Despite significant advances, mortality from brain tumors remains high with five-year survival rates of 36%, according to the National Cancer Institute. More accurate diagnoses might improve the situation, but tissue biopsies are invasive and can miss important information about a tumor’s make-up. Imaging-based methods, meanwhile,...
