by Katie Marquedant, Massachusetts General Hospital Correlation analysis between SCD expression and sensitivity to YTX-7739. (A) Immunoblot analysis (left) of SCD expression in YTX-7739-sensitive and -resistant GSCs lines. Also shown (right) is the correlation analysis between the EC50 of YTX-7739 and SCD expression in all 12 GSCs lines. Western-blot bands of SCD normalized to GAPDH were...
By BRIGHAM AND WOMEN’S HOSPITAL JANUARY 5, 2023 Researchers at Brigham and Women’s Hospital have found a way to use cancer cells to fight cancer. In a study published in Science Translational Medicine, the team led by Khalid Shah demonstrated that their cell therapy could eliminate established tumors and create long-term immunity in an advanced mouse model of glioblastoma,...
Despite significant advances, mortality from brain tumors remains high with five-year survival rates of 36%, according to the National Cancer Institute. More accurate diagnoses might improve the situation, but tissue biopsies are invasive and can miss important information about a tumor’s make-up. Imaging-based methods, meanwhile, do not offer sufficient sensitivity and resolution. Now, researchers reporting in ACS Nano have...
by American Chemical Society Graphical abstract. Credit: ACS Nano (2022). DOI: 10.1021/acsnano.2c04187 Despite significant advances, mortality from brain tumors remains high with five-year survival rates of 36%, according to the National Cancer Institute. More accurate diagnoses might improve the situation, but tissue biopsies are invasive and can miss important information about a tumor’s make-up. Imaging-based methods, meanwhile,...
The discovery, which combines innovative synthetic chemistry and cutting-edge mechanistic studies in molecular biology, offers a potentially powerful new approach to treating drug-resistant glioma tumors that form in the brain and spinal cord. “A major problem in treating gliomas is that patients can rapidly develop resistance to the drug temozolomide, which has been the backbone of...
by University of Bristol Concept of how mathematical modeling may be used in the development and deployment of blood-based biomarkers for brain tumors. This figure summarizes the role mathematical modeling could play in blood-based liquid biopsy development and implementation. Credit: Dr Johanna Blee, University of Bristol. University of Bristol research could lead to better detection...
by Graciela Gutierrez, Baylor College of Medicine Credit: Pixabay/CC0 Public Domain A team led by researchers at Baylor College of Medicine has shed new light on the genetic regulation of brain tumor behavior. Published in the Proceedings of the National Academy of Sciences, the study reveals that, contrary to what is expected, gene expression regulator Sox9,...
by Brigham and Women’s Hospital Credit: Unsplash/CC0 Public Domain Immunotherapy has revolutionized treatment for many forms of cancer, but glioblastoma multiforme (GBM), the most common and deadly form of brain cancer, has remained untouched. GBM tumors are sometimes referred to as “cold”—that is, the immune system has a difficult time detecting and targeting them, allowing...
by Josh Barney, University of Virginia Dr. Daniel “Trey” Lee is researching whether an immunotherapy treatment that has been successful in treating blood cancers can be used to attack solid tumors, like brain tumors. Credit: Dan Addison, University Communications New research from UVA Cancer Center and UVA Children’s Hospital could be a “game-changer” in the...
by University of Surrey Credit: Unsplash/CC0 Public Domain Findings from a seven-year research project suggests that there could be a new approach to treating one of the most common and devasting forms of brain cancer in adults—Glioblastoma Multiforme (GBM). In a peer-reviewed study published by BMC Cancer, scientists from the University of Surrey show that...
