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Study reveals function of little-understood synapse in the brain

by Oregon Health & Science University Credit: CC0 Public DomainNew research from Oregon Health & Science University for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer’s disease, to a type of brain cancer known as...

Scientists use blood test to track gene expression in the brain
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Scientists use blood test to track gene expression in the brain

by Kayt Sukel, Rice University Scan of mouse hippocampus and cortex, where the red signal derives from immunostaining for the synthetic marker developed by the Szablowski lab and the blue from the immunostaining of c-Fos, an endogenous protein whose production is heightened by increased neuronal activity. Credit: Szablowski lab/Rice UniversityThe brain is the most protected organ...

Drug beliefs produce a dose-dependent effect in the brain, study finds
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Drug beliefs produce a dose-dependent effect in the brain, study finds

By Paul McClure A study has found that a person’s drug beliefs can produce a dose-dependent effect in the brainDepositphotos Researchers have shown, for the first time, that a person’s beliefs about nicotine influences brain activity, producing a dose-dependent effect that was only thought to occur with pharmaceutical agents. In addition to providing an explanation for...

Study identifies new concepts for GLP-1 action in the brain
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Study identifies new concepts for GLP-1 action in the brain

by Lunenfeld-Tanenbaum Research Institute Graphical abstract. Credit: Cell Metabolism (2023). DOI: 10.1016/j.cmet.2023.11.009 Researcher Dr. Daniel Drucker has much to be proud of, as the GLP-1-based diabetes drugs hailing from his early research are named the 2023 breakthrough of the year by the Science Magazine. Not only have millions of people with type 2 diabetes benefitted from...

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Riding Sound Waves in the Brain

ETH Zurich researchers have shown for the first time that microvehicles can be steered through blood vessels in the brains of mice using ultrasound. They hope this will eventually lead to treatments capable of precisely delivering drugs.Neuroscience, brain – associative rendering. Neuroscience, brain – associative rendering. Image credit: Milad Fakurian via Unsplash, free license Brain...

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Our Brains Are Not Able to ‘Rewire’ Themselves, Despite What Most Scientists Believe, New Study Argues

Contrary to the commonly-held view, the brain cannot rewire itself to compensate for the loss of sight, an amputation or stroke, for example, say scientists from the University of Cambridge and Johns Hopkins University. Graphic representing brain circuits. Credit: GDJ, Public Domain Writing in eLife, Professors Tamar Makin (Cambridge) and John Krakauer (Johns Hopkins) argue...

New study is first to find brain hemorrhage cause other than injured blood vessels
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New study is first to find brain hemorrhage cause other than injured blood vessels

by University of California, Irvine t-BHP-treated RBC stall in cerebral blood vessels and impair cerebral blood flow velocity shown by in vivo high-resolution two-photon imaging in mice. Schematic of the experimental design (A). RBC were collected from FVB/NJ mice, treated with control PBS or the oxidative stressor t-BHP, then labeled with the PKH26 fluorescent dye...

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AHA Reviews Impact of Aggressive LDL Lowering on the Brain

Megan Brooks A newly published scientific statement from the American Heart Association (AHA) focuses on the impact of aggressive low-density lipoprotein cholesterol (LDL-C) lowering on the risk for dementia and hemorrhagic stroke. “The brain is the body’s most cholesterol-rich organ, and some have questioned whether aggressive LDL-C lowering induces abnormal structural and functional changes,” the...

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Probiotics delivered in biofilm state protect the intestines and brain in NEC model

Biofilm formulation of Limosilactobacillus reuteri protects against necrotizing enterocolitis in piglet model Peer-Reviewed Publication NATIONWIDE CHILDREN’S HOSPITAL (COLUMBUS, Ohio) – Necrotizing enterocolitis (NEC) is a debilitating and deadly condition that affects infants who were born preterm. In NEC cases, intestinal tissues become inflamed, and in severe cases there is ischemia and death of the involved...