by Kristine Zengeler, The Conversation Graphical abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.09.030 Many neurodegenerative diseases, or conditions that result from the loss of function or death of brain cells, remain largely untreatable. Most available treatments target just one of the multiple processes that can lead to neurodegeneration, which may not be effective in completely addressing disease symptoms or progress,...
by Lund University Visual representation of the role of microglia activation in longitudinal accumulation of amyloid and tau aggregates. When microglia are in a homeostatic state, they do not protect against the accumulation of amyloid and tau aggregates, which increase over time in individuals at risk of developing Alzheimer’s disease (AD) (a). In contrast, when...
by Indiana University School of Medicine Credit: CC0 Public Domain When immune cells move throughout the brain, they act as the first line of defense against viruses, toxic materials, and damaged neurons, rushing over to clear out them. Researchers at Indiana University School of Medicine have been investigating how these immune cells in the brain—microglia—relate...
