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Cancer ‘guardian’ breaks bad with one switch
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Cancer ‘guardian’ breaks bad with one switch

by Mike Williams,  Rice University A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone sequence protected by the N-terminus tail in wild-type p53 but exposed by the mutation of a single amino acid. The strongest...