Combination therapy reduces tumor size, dramatically improves survival in mice NORTHWESTERN UNIVERSITY CHICAGO — When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targeting breast cancer cells...
Tag: <span>Breast Cancer</span>
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Smartphones may help detect diabetes
by University of California, San Francisco Researchers at UC San Francisco have developed a ‘digital biomarker’ that would use a smartphone’s built-in camera to detect Type 2 diabetes—one of the world’s top causes of disease and death—potentially providing a low-cost, in-home alternative to blood draws and clinic-based screening tools. Type 2 diabetes affects more than...
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A metabolic enzyme as a potential new target for cancer immune therapies
by German Cancer Research Center The metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system. This was discovered by scientists at the German Cancer Research Center (DKFZ) and the Berlin Institute of Health (BIH). The enzyme that activates the dioxin receptor is produced in large quantities by tumor cells....
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Age, education, and surgical history affect hormone use after oophorectomy
New study identifies frequency of hormone therapy use and predictors of its use in women who underwent preventive oophorectomy as a result of carrying the BRCA gene THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS) CLEVELAND, Ohio (August 12, 2020)–Removal of the ovaries before natural menopause (surgical menopause) often exacerbates menopause symptoms and places women at increased...
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Immunotherapy-resistant cancers eliminated in mouse study
Antibody that blocks TREM2 protein frees immune cells to reject cancer WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IMMUNE CELLS INFILTRATE A HUMAN TUMOR IN THE FOUR COLORIZED IMAGES ABOVE. IN A MOUSE STUDY, RESEARCHERS AT WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST. LOUIS HAVE FOUND THAT AN… view more CREDIT: WILLIAM VERMI/MARTINA MOLGORA Immunotherapy has revolutionized...
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Scientists discover that a normal DNA repair process can become a major source of mutations in cancer
by Institute for Research in Biomedicine – IRB Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer. The best known type of local hypermutation, called a mutation shower or thunderstorm, is quite uncommon and it leads to many mutations accumulated in...
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HDAC6 can control tumor growth and halt metastasis in triple-negative breast cancer
by George Washington University Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the top-tier journal Cancer Research by investigators at the George Washington University (GW) Cancer Center. Immunotherapy—the use of drugs to stimulate one’s own immune system to...
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Genetic tool can identify Asian women at higher risk of breast cancer
by University of Cambridge Three-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by Tom Misteli, Ph.D., and Karen Meaburn, Ph.D. at the NIH IRP. A genetic study in Asian women, led by Malaysian scientists in collaboration with Singapore...
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Study pinpoints women who benefit less from 3D mammograms
Digital breast tomosynthesis improves cancer detection and reduces recalls, but women with extremely dense breasts don’t fully realize that advantage. UNIVERSITY OF WASHINGTON HEALTH SCIENCES/UW MEDICINE A RADIOLOGY TECHNICIAN HELPS PREPARE A PATIENT FOR A SCREENING MAMMOGRAPHY AT UW MEDICAL CENTER-ROOSEVELT IN SEATTLE, WASHINGTON. view more CREDIT: UW MEDICINE A new comparison of two breast-screening...
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Drug-induced interstitial lung disease in breast cancer patients
A lesson we should learn from multi-disciplinary integration Announcing a new article publication for BIO Integration journal. In this case report the authors Zijun Zhao, Zhanghai He, Hongyan Huang, Jiewen Chen, Shishi He, Ailifeire Yilihamu and Yan Nie from Sun Yat-sen University, Guangzhou, China consider drug-induced interstitial lung disease in breast cancer patients. Taxanes represented...