DARTMOUTH HEALTH LEBANON, NH— Advanced estrogen receptor-positive (ER+) breast cancer can be especially difficult to treat. A new study by researchers at Dartmouth Cancer Center led by Todd W. Miller, PhD, shows promise in using a combination of estrogen and a PARP inhibitor (a drug that suppresses DNA damage repair), to treat this type of cancer. Estrogen...
Tag: <span>Breast Cancer</span>
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Most women diagnosed with early breast cancer can expect to become long term survivors, say experts
BMJ Most women diagnosed with early stage breast cancer today can expect to become long term cancer survivors, finds a study published by The BMJ today. The findings show that the average risk of dying from breast cancer in the five years after a diagnosis has fallen from 14% to 5% since the 1990s. For those diagnosed...
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BORIS gene mutation and expression: Link to breast cancer progression
by Impact Journals LLC Figure 4: Representative immunohistochemical slides showing (A) Low protein expression (+) (scale bar 20 μm), (B) Moderate protein expression (++) (scale bar 100 μm), and (C) High protein expression (+++) (scale bar 100 μm) of BORIS protein in Indian female breast cancer cases. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28442 A new research paper titled “Association of...
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A HER2-targeting peptide drug conjugate with better penetrability for effective breast cancer therapy
by Compuscript Ltd Schematic diagram and pharmacokinetics of HER2-TP-cy5.5 and HER-TA-cy5.5 conjugate synthesis. (A) Schematic representation of the utilization of HER2-targeting peptide/antibody and Cyanine5.5-NHS ester (Cy5.5) to form conjugates. (B) Purification of the conjugates, (C) Collection of the purified components. (D) The circulation time of free Cy5.5 and Cy5.5-labeled peptide/antibody after intravenous injection in mice...
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Molecular trigger for breast cancer development identified endocrinology & metabolism
by Harvard Medical School Credit: Pixabay/CC0 Public Domain In what may turn out to be a long-missing piece in the puzzle of breast cancer, Harvard Medical School researchers have identified the molecular sparkplug that ignites cases of the disease currently unexplained by the classical model of breast-cancer development. A report on the team’s work is published...
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Depression found to affect the care and survival of patients with breast cancer
by Wiley Credit: Unsplash/CC0 Public Domain In a recent study, having depression before or after a breast cancer diagnosis was associated with a lower likelihood of survival. The findings are published in the journal Cancer. For the study, Bin Huang, DrPH, of the University of Kentucky Markey Cancer Center, and his colleagues analyzed data from the Kentucky Cancer Registry...
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Antibiotics after breast cancer linked to poorer survival, study finds
by Krista Conger, Stanford University Medical Center Landmarking analysis to evaluate the impact of antimicrobial exposure on survival over time on N = 772 independent patients. Data were presented as the hazard ratios ± 95% confidence intervals that reflect the risk of ongoing antimicrobial exposure at yearly intervals post-diagnosis and are plotted for the cumulative exposure definitions of total and...
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Dietary supplement helps combat resistance in breast cancer
UNIVERSITY OF BASEL Many cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medication. This is the case, for example, with alpelisib, a drug that has been approved for use in Switzerland for the past few years as a treatment for advanced breast...
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New breast cancer susceptibility gene candidate identified
by Justin Jackson , Medical Xpress Credit: Unsplash/CC0 Public Domain A paper published in the American Journal of Human Genetics proposes ATRIP gene variants as a breast cancer susceptibility gene candidate based on a study of women without any of the known breast cancer-associated gene variants. The team of Canadian and Polish researchers led by the University of Toronto...
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Certain Birth Control Pills Increase Risk Of Breast Cancer By Up To 30%, University Of Oxford Researchers Find
There is a relative increase of around 20% to 30% in breast cancer risk associated with current or recent use of either combined oral or progestagen-only contraceptives.” By Amanda Prestigiacomo Mar 25, 2023 Peter Dezeley via Getty Images Hormonal contraceptives come with an increased risk of breast cancer, according to a new study conducted by...