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Study suggests new molecular target for therapeutic interventions aimed at C. difficile infection
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Study suggests new molecular target for therapeutic interventions aimed at C. difficile infection

by  University of California, Irvine The VPI10463 and M68 represent the classic and the hypervirulent C. difficile, respectively. GTD-VPI preferentially modifies Rho family GTPases (Cdc42, for example) by glucosylation, while GTD-M68 more effectively modifies R-Ras. Due to their different selectivity toward Rho or Ras family GTPases, these two different TcdB variants cause two distinct types of...