OSAKA UNIVERSITY IMAGE: WE PROPOSE THAT MALIGNANT HYPERTHERMIA OCCURS WHEN RUNAWAY THERMOGENESIS IS CAUSED BY A HEAT-SENSITIVE CA2+-RELEASE CHANNEL (RYR1). ANESTHESIA IS KNOWN TO TRIGGER CA2+ RELEASE THROUGH MUTANT RYR1 VARIANTS, FACILITATING THERMOGENESIS IN MUSCLE CELLS (GRAY ARROWS). IN THE PRESENT STUDY, WE FOUND THAT APPLYING HEAT CAUSES CA2+ RELEASE THROUGH RYR1 BY A MECHANISM...
