Scientists identify treatment target that disrupts proteins’ interaction, offering hope for new therapeutic approachPeer-Reviewed Publication CITY OF HOPE PROTEIN SURFACE (LEFT) AND RIBBON (RIGHT) MODELS OF INTEGRIN ΑV’S Β-PROPELLER DOMAIN ILLUSTRATE THE CAPACITY OF CPD_AV2 (YELLOW) IN DISRUPTING THE INTERACTION BETWEEN INTEGRIN Β5’S ΒA LOOP (CYAN; GREEN INDICATES THE KEY INTERACTING RESIDUE LYSINE 287) AND...
by Karolinska Institutet Fig. 1 Elevated eIF4A3 expression in cancer is correlated with a high RiBi rate and poor prognosis. (A) Representative GENT2 (Gene Expression database of Normal and Tumor tissues 2)-derived comparison of eIF4A3 mRNA levels in various cancer types and their normal counterpart tissues (****P < 0.001). (B) Correlation of eIF4A3 mRNA expression levels...
by Uppsala University Credit: Pixabay/CC0 Public Domain Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells’ metabolism. These changes can be used as markers to discriminate whether a...
by Karolinska Institutet In a new study published in the journal Cell Death & Differentiation, researchers at Karolinska Institutet have conducted a translational study that identified a new mechanism for controlling the breakdown of glucose in several different cancer forms. The discovery could lead to new therapeutic strategies aimed to reduce cancer growth. A common problem with the current...
