by Centro de Investigación Médica Aplicada (CIMA) Universidad de Navarra Replication stress induces lncRNAs associated to replicating chromatin. a (Top) Mechanism of action of hydroxyurea (HU) RNR: ribonucleotide reductase. (Bottom) Immunoblot analysis HCT116 cells treated with HU 1 mM for 8 h followed by 3 h recovery shows the reversible effect of HU on replication stress markers p-ATR,...
Tag: <span>cancer cells</span>
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How early-stage cancer cells hide from the immune system
A new study finds precancerous colon cells turn on a gene called SOX17, which helps them evade detection and develop into more advanced tumors.Peer-Reviewed Publication MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — One of the immune system’s primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells...
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New technique could make human T cells 100 times more potent at killing cancer cells
by Northwestern University Credit: Pixabay/CC0 Public DomainScientists at the UC San Francisco (UCSF) and Northwestern Medicine may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself. By studying mutations in malignant T cells that cause lymphoma, they zeroed in on one that imparted exceptional potency to...
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MOLECULAR JACKHAMMERS RUPTURE CANCER CELLS
POSTED BY TEXAS A&M UNIVERSITY“From the medical point of view, when this technique is available, it will be beneficial and less expensive than methods such as photothermal therapy, photodynamics, radio-radiation, and chemotherapy,” says Jorge Seminario. A new technique could offer a much safer and more effective alternative to current cancer treatments. Just as jackhammers can...
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Molecular jackhammers’ ‘good vibrations’ eradicate cancer cells
Light-induced whole-molecule vibration can rupture melanoma cells’ membrane The Beach Boys’ iconic hit single “Good Vibrations” takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some molecules to vibrate strongly when...
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New compound could lead to therapeutics that selectively kill cancer cells
by Children’s Medical Research Institute (CMRI) Credit: Cell Chemical Biology (2023). DOI: 10.1016/j.chembiol.2023.11.008 A team from Children’s Medical Research Institute has discovered a new way to impair cancer cell growth, which could lead to the development of a new class of cancer therapeutics with minimal side-effects on normal cells. Professor Hilda Pickett, who leads CMRI’s...
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Discovery of an antibody that stimulates the immune system to eliminate cancer cells
by University of Montreal CD47 interacts in cis with SLAMF7 on tumor cells. a, Binding of CD47-Fc (red line) to WT or Sirpa−/− BMDMs assayed by flow cytometry. Filled curves, Ctrl Fc. b, Mass spectrometry analysis of Flag mAb immunoprecipitates from L1210 derivatives expressing a Flag-tagged variant of mCD47 showing various potentially associated proteins. c, Co-IP...
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Purdue pharmaceutical compound sounds the alarm on cancer cells and unleashes T cells
College of Pharmacy researchers develop small-molecule degrader to target enzyme that plays a role in tumor cells and the immune system Peer-Reviewed Publication PURDUE UNIVERSITY ZHONG-YIN ZHANG OF PURDUE UNIVERSITY’S COLLEGE OF PHARMACY AND THE PURDUE INSTITUTE FOR DRUG DISCOVERY LEADS A TEAM THAT HAS CREATED A NOVEL CANCER IMMUNOTHERAPY COMPOUND THAT DEGRADES AN ENZYME...
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Study finds carcinogen exposure makes cancer cells more susceptible to immune attack
by Liz Murphy, Massachusetts General Hospital Carcinogen-exposed cancer cells transform that nature of tumor-infiltrating macrophages from immunosuppressive (left) to immune activating agents (right), rendering the cancer immunogenic. Green color highlights macrophages and purple color is an immunosuppressive mark on macrophages. Credit: Dr. Mei Huang.While carcinogens are widely known to be perpetrators of cancer, a new study...
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Significant discovery in breast cancer research: Inhibiting collagen XVIII function weakens cancer cells
by University of Oulu A microscopic image of a breast cancer sample, in which collagen XVIII is stained in brown within the cancer cells spreading into the surrounding tissue and in the blood vessels bordering the tumor nest. Credit: Devarajan et al. J Clin Invest 133(18):e159181, 2023Researchers at the University of Oulu have made a discovery...