Light-induced whole-molecule vibration can rupture melanoma cells’ membrane The Beach Boys’ iconic hit single “Good Vibrations” takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some molecules to vibrate strongly when...
by Children’s Medical Research Institute (CMRI) Credit: Cell Chemical Biology (2023). DOI: 10.1016/j.chembiol.2023.11.008 A team from Children’s Medical Research Institute has discovered a new way to impair cancer cell growth, which could lead to the development of a new class of cancer therapeutics with minimal side-effects on normal cells. Professor Hilda Pickett, who leads CMRI’s...
by University of Montreal CD47 interacts in cis with SLAMF7 on tumor cells. a, Binding of CD47-Fc (red line) to WT or Sirpa−/− BMDMs assayed by flow cytometry. Filled curves, Ctrl Fc. b, Mass spectrometry analysis of Flag mAb immunoprecipitates from L1210 derivatives expressing a Flag-tagged variant of mCD47 showing various potentially associated proteins. c, Co-IP...
College of Pharmacy researchers develop small-molecule degrader to target enzyme that plays a role in tumor cells and the immune system Peer-Reviewed Publication PURDUE UNIVERSITY ZHONG-YIN ZHANG OF PURDUE UNIVERSITY’S COLLEGE OF PHARMACY AND THE PURDUE INSTITUTE FOR DRUG DISCOVERY LEADS A TEAM THAT HAS CREATED A NOVEL CANCER IMMUNOTHERAPY COMPOUND THAT DEGRADES AN ENZYME...
by Liz Murphy, Massachusetts General Hospital Carcinogen-exposed cancer cells transform that nature of tumor-infiltrating macrophages from immunosuppressive (left) to immune activating agents (right), rendering the cancer immunogenic. Green color highlights macrophages and purple color is an immunosuppressive mark on macrophages. Credit: Dr. Mei Huang.While carcinogens are widely known to be perpetrators of cancer, a new study...
by University of Oulu A microscopic image of a breast cancer sample, in which collagen XVIII is stained in brown within the cancer cells spreading into the surrounding tissue and in the blood vessels bordering the tumor nest. Credit: Devarajan et al. J Clin Invest 133(18):e159181, 2023Researchers at the University of Oulu have made a discovery...
by Dan Worthley, The Conversation Credit: Shutterstock As medical technology advances, many diseases could be detected, prevented and cured with cells, rather than pills. This branch of medicine is called cellular or cell therapy. It’s already used in clinical practice in some situations, such as patients receiving fecal microbial transplants (“poo transplants”) when they have a severe gastrointestinal infection,...
Using an RNA-based drug delivered to multiple myeloma blood cancer cells by targeted lipid nanoparticles, researchers at Tel Aviv University (TAU) destroyed 90% of the cells under laboratory conditions and 60% of the cells in human tissues. The researchers developed lipid-based nanoparticles, similar to those used in the COVID-19 vaccine, containing RNA molecules that silence the gene...
by Justin Jackson , Medical Xpress Conversion of BCL6 auto-inhibitory pathway to feedforward loop. Credit: Nature (2023). DOI: 10.1038/s41586-023-06348-2 Scientists at Stanford University have found a way to induce cell death in cancer cells with a method that could be effective in around 50% of cancers. In a paper, “Rewiring cancer drivers to activate apoptosis,” published in Nature,...
HEALTH31 July 2023 By DAVID NIELD Killer T cells surround a cancer cell. (NIH Image Gallery/Flickr/Public Domain) One of the challenges in treating cancer is stopping it from metastasizing, and a new study reveals one of the fundamental mechanisms through which this happens. Now we know about this mechanism, perhaps we can stop it. Key to this newly...
