by Singapore University of Technology and Design Top left, Thermograph of the sample upon application of electrical signal; Top right, Transmission electron microscopy image of MNM; Bottom left, Binding interface of the virus-cancer cell protein structure; Bottom right, Schematic diagram of the composition and process used to construct the MNM. Credit: Pharmaceutics (2022). DOI: 10.3390/pharmaceutics15010106 Electro-thermal therapy, which...
by Rockefeller University Arginine codons and residues are frequently lost and are associated with an increase in ASS1 expression. (A) Heatmap depicting codons gained (red) and lost (blue) across the TCGA. Gains and losses are normalized to the total number of missense and silent mutation events per sample for each cancer type. (B) Qualitative chord diagram...
by Delthia Ricks, Medical Xpress Lymphoid BLaER1 cells undergo PANX1-dominant lysis. (A to C) BLaER1 cells were treated with topoisomerase poisons doxorubicin (2 μM) or etoposide (50 μM) for 24 hours. Concurrent treatment with PANX1 inhibitor trovafloxacin (20 μM) or NLRP3 inflammasome inhibitor MCC950 (10 μM) were as indicated. In (A and C), quantification of...
by Johns Hopkins University School of Medicine Schematic showing DRP-104’s bio-activation to DON in tumor and bio-inactivation to an inert metabolite in GI tissues. Credit: Jennifer E. Fairman, CMI, FAMI, Department of Art as Applied to Medicine Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues...
By Nick Lavars November 14, 2022 Scientists have discovered a new type of electrical activity in cancer cells Depositphotos By using machine learning and cutting-edge microscopes, scientists have uncovered what they believe to be a new form of communication between cancer cells. Described as a “type of electrical language,” the discovery may be key to...
by Susann Huster, Leipzig University Credit: Pixabay/CC0 Public Domain The ancient Egyptians, as described in the Ebers Papyrus, already knew that palpation—feeling for hardened lumps—can help diagnose breast cancer. Palpation is still an important element in early screening for breast cancer. On the other hand, measurements on individual cancer cells show that they are softer...
A genetically modified version of the herpes virus has shown great potential in treating advanced cancers, according to a report by the Institute of Cancer Research in London published on Thursday. A promising therapy Although the treatment is still in early trials, researchers have found that RP2, a modified version of the herpes simplex virus,...
by Catarina Pietschmann, Max Delbrück Center for Molecular Medicine Three-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Credit: NCI Center for Cancer Research, National Cancer Institute, National Institutes of Health Every cell has two mechanisms for repairing DNA single- or double-strand breaks, which...
by University of Basel High-throughput drug screen reveals estrogen receptor α (ERα) induction in triple-negative breast cancer (TNBC) upon polo-like kinase 1 (PLK1) inhibition. A Schematic of the high-throughput drug screen to identify inhibitors that induce ERα signaling in TNBC. Cells without active ERα signaling do not express GFP, whereas cells with active ERα signaling...
by German Cancer Research Center Human cancer cells (cell nucleus in blue) feeding on protein (Albumin, labeled in green). The proteins are digested and broken down into amino acids in the lysosomes (magenta). Credit: W. Palm / DKFZ Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge...
