by St. Jude Children’s Research Hospital Graphic abstract. Credit: Cell (2022). DOI: 10.1016/j.cell.2022.07.025 Scientists at St. Jude Children’s Research Hospital have identified how some cancer cells cheat treatment-induced cell death. In doing so, they persist and lead to cancer recurrence. The findings may serve as the basis for drugs that prevent relapses by inhibiting cancer cells from...
by University of Michigan A model demonstrating how this type of novel drug is absorbed through the lymphatic system. Credit: Danielle Dobbs/Michigan Medicine A team of University of Michigan researchers is developing a new anti-cancer drug that is absorbed through the gut’s lymphatic system rather than blood vessels, potentially outmaneuvering the molecular signaling pathways that...
However, patients need not worry about locusts swarming their doctors’ offices. Rather, the researchers say this work could provide the basis for devices that use insect sensory neurons to enable the early detection of cancer using only a patient’s breath. “NOSES ARE STILL STATE OF THE ART. THERE’S REALLY NOTHING LIKE THEM WHEN IT COMES...
by Katherine Unger Baillie, University of Pennsylvania Researchers found a mechanism by which cancers keep T cells from infiltrating tumors. In areas of a tumor with low levels of a molecule called HRS with a phosphate group added, T cells could penetrate (right panels), but they were nearly blocked in areas with high levels of...
The findings of a large-scale screen could help researchers design nanoparticles that target specific types of cancer. Using nanoparticles to deliver cancer drugs offers a way to hit tumors with large doses of drugs while avoiding the harmful side effects that often come with chemotherapy. However, only a handful of nanoparticle-based cancer drugs have been FDA-approved. A...
by Leslie Cantu, Medical University of South Carolina Histopathology representative images of stomach hyperkeratosis and thymus cortical degeneration. (A) H&E stained images of stomach sections from a vehicle control mouse (left panel) and a Doxil treated mouse (right panel). Images shown at ×10 magnification. Arrow highlights hyperkeratosis. (B) H&E stained images of thymus sections from...
By CALIFORNIA INSTITUTE OF TECHNOLOGY JULY 8, 2022 An artist’s depiction of a bacterial cell. Credit: Centers for Disease Control and Prevention/James Archer Since its inception, chemotherapy has proven to be a valuable tool in treating many kinds of cancers, but it has a significant drawback. In addition to killing cancer cells, it can also destroy healthy...
by Columbia University Credit: Unsplash/CC0 Public Domain Columbia and MIT researchers are revealing the surprising reasons why cancer cells are often forced to rely on fat imports, a finding that could lead to new ways to understand and slow down tumor growth. The research, led by Dennis Vitkup, Ph.D., associate professor of systems biology at...
by Max Delbrück Center for Molecular Medicine Integration of multiple datasets enables robust extraction of informative gene sets. A, B ikarus workflow. ikarus is a two-step procedure for classifying cells. In the first step, integration of multiple expert labeled datasets enables the extraction of robust gene markers. The gene markers are then used in a...
JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IMAGE: FIRST AUTHOR, ALBERTO BUENO-COSTA AND CHIEF SUPERVISOR, DR. MANEL ESTELLER CREDIT: JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE Barcelona, June 9th, 2022. A new research describes how highly proliferative leukemia cells end up becoming normal cells that no longer multiply, by changing the chemical modifications -the so-called epigenetics- of a type of...
