by Institute of Cancer Research USP25 is highly expressed and enzymatically active in PDAC compared to normal pancreatic tissue, which correlated with poor patient survival. a Histological and immunohistochemical analysis of Usp25 expression in normal pancreatic and KPCY tumor tissues. Scale bar is 100 µm. b Quantification of Usp25 positive staining area (n = 6 biologically independent animals...
By Nick Lavars April 27, 2022 A new study has demonstrated how star-shaped devices can be introduced into cells and cause their demise CSIC The field of nanomedicine is progressing rapidly and in recent years has opened up all kinds of exciting possibilities, with scientists showing how tiny particles could be deployed to deliver drugs, fight inflammation and prevent...
by Bob Yirka, Medical Xpress Credit: Science (2022). DOI: 10.1126/science.abl3855 A team of researchers from Genetch, Inc., the Howard Hughes Medical Institute and the Peter MacCallum Cancer Center, has found that cancerous tumor cells are able to survive attacks by repairing holes in their membranes caused by a protein released from T cells. In their paper published...
by Emma Rose Johnson, Rush University Medical Center Prostate cancer cells. Credit: NIH Image Gallery Prostate cancer affects one in every eight men during their lifetime, making it the most prevalent form of cancer for males. For many, the standard of care means facing aggressive treatments that include radiation and the freezing or removal of...
by Greta Friar, Whitehead Institute for Biomedical Research Credit: Jennifer Cook-Chrysos/Whitehead Institute Cancer is at its most deadly when it spreads and forms tumors in new tissues. This process, called metastasis, is responsible for the vast majority of cancer deaths, and yet there is still a lot that researchers do not know about how and...
MEDICAL COLLEGE OF WISCONSIN IMAGE: IMAGE: ADVANCED MRI SHOWS A 93% REDUCTION IN CONTRAST ENHANCING TUMOR VOLUME (T1+C: YELLOW ARROW) IN ONE RAT RESPONDING TO GAM TREATMENT. IB’S QUANTITATIVE DELTA T1 (ΔT1) MAPS ALLOW VISUALIZATION OF “TRUE” TUMOR ENHANCEMENT FREE OF CONFOUNDING BLOOD PRODUCTS. IB’S RELATIVE CEREBRAL BLOOD VOLUME (RCBV) NOTICEABLY DECREASED BY DAY 50...
by Massachusetts General Hospital Credit: Pixabay/CC0 Public Domain Cancer cells initially confined to a single location in the body can eventually spread, or metastasize, to distant sites such as the bone, lung, liver and brain, where they take on new characteristics depending on the particular tissue environment. In a study published in Cancer Research, a team...
by Bob Yirka, Medical Xpress Substitutants are presented at the cell surface and activate T cells. Credit: Nature (2022). DOI: 10.1038/s41586-022-04499-2 An international team of researchers has found that some cancer cells are able to make up for a loss of tryptophan by conducting codon reassignments that allow for the production of phenylalanine “substitutants” (a word they...
ROCKEFELLER UNIVERSITY PRESS IMAGE: PET IMAGING (RIGHT) SHOWS THE ACCUMULATION OF IRON IN METASTATIC TUMORS GROWING IN THE SPINE AND LIVER OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA. CREDIT: © 2022 JIANG ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. HTTPS://DOI.ORG/10.1084/JEM.20210739 Researchers at the University of California, San Francisco (UCSF), have discovered that cells carrying the...
POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH) IMAGE: A) SCHEMATIC DIAGRAM OF A REDOX-TRIGGERED SELF-IMMOLATIVE NITRIC OXIDE PRODRUG AND ITS APPLICATION (CONJUGATION WITH A CARRIER), AND THE PRINCIPLE OF REDOX-TRIGGERED SELF-IMMOLATIVE FRAGMENTATION. B) SCHEMATIC OF THE LYMPHATIC DELIVERY AND TREATMENT PROCESS OF REDUCTIVE NITRIC OXIDE PRODRUGS FOR THE TREATMENT OF METASTATIC CANCER. CREDIT: POSTECH Assassins...
