by University of Montreal Graphical abstract. Credit: DOI: 10.1016/j.celrep.2021.110111 Awakening the immune system’s instinct for destroying cancer, using two molecules located on the surface of macrophages: that’s the promising avenue opening up from recent laboratory work of Dr. André Veillette. Director of the Molecular Oncology Research Unit of the Montreal Clinical Research Institute (IRCM) and...
by University of Michigan Credit: CC0 Public Domain When cancer cells metastasize, they morph, becoming missile-shaped in order to penetrate into other tissues throughout the body. In fact, to travel throughout the body, metastatic cancer cells must change their phenotypes—their physical characteristics. This change allows stationary, epithelial cells which compose the barriers of our organs...
by Osaka University Fig.1 Antisense oligonucleotide (ASO) targeting Arl4c inhibits pancreatic cancer metastasis. Credit: Akikazu Harada Pancreatic cancer is very aggressive and, unfortunately, has a poor prognosis with a 5-year survival of only 5%. Most deaths related to pancreatic cancer are due to metastasis, which occurs when the tumor invades other organs. Treatments to stop tumor...
ROCKEFELLER UNIVERSITY PRESS IMAGE: COMPARED WITH A CONTROL (LEFT PANELS), C26 TREATMENT (RIGHT PANELS) REDUCES THE NUMBER OF METASTATIC TUMORS IN THE LUNGS OF MICE INJECTED WITH HSNCC CELLS. CREDIT: © 2021 KHALIL ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. A new therapeutic approach prevents the growth of metastatic tumors in mice by...
by Keck School of Medicine of USC Credit: Pixabay/CC0 Public Domain Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy. To carry out these behaviors, each cancer cell uses its genes to make the needed molecules...
by Bob Yirka, Medical Xpress Credit: Pixabay/CC0 Public Domain A team of researchers working at the University of New Mexico Health Science Center has found some success in creating a cancer vaccine by coating cancer cells in silica and injecting them into test mice. In their paper published in the journal Nature Biomedical Engineering, the group...
by Tohoku University Perfusion defect in the lymph node visualized by contrast-enhanced micro-computed tomography and high-frequency ultrasound (arrows). Credit: Tohoku University If not caught quickly, cancer cells often spread to other organs in a process called metastasis. Lymph nodes (LNs) are the organs with the highest risk of metastasis. Metastasis in the LNs also influences...
By Nick Lavars October 20, 2021 Scientists have discovered a new way to enhance the ability of T cells to fight tumorsMIT/iStockphoto Scientists at MIT have made a discovery that could expand the potential of immunotherapy, enabling it to treat wider variety of cancers. The breakthrough stems from a newfound ability to jump-start the body’s...
Cancer cells aren’t good citizens—they’re selfish and lazy, loitering around in clusters, stealing resources from neighboring cells, and refusing to contribute to the good of the community. But the vast majority aren’t murderers. Out of every 10,000 cells that make up a tumor, 9,999 are basically innocent. Deadbeats, sure, but not criminals. That one, though? It’s...
AMERICAN ASSOCIATION FOR CANCER RESEARCH PHILADELPHIA – A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint inhibitors in preclinical cancer models, according to results presented at the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics, held October 7-10, 2021. Immune checkpoint inhibitors are commonly combined with...
