by Massachusetts General Hospital Credit: Pixabay/CC0 Public Domain Cancer cells initially confined to a single location in the body can eventually spread, or metastasize, to distant sites such as the bone, lung, liver and brain, where they take on new characteristics depending on the particular tissue environment. In a study published in Cancer Research, a team...
by Bob Yirka, Medical Xpress Substitutants are presented at the cell surface and activate T cells. Credit: Nature (2022). DOI: 10.1038/s41586-022-04499-2 An international team of researchers has found that some cancer cells are able to make up for a loss of tryptophan by conducting codon reassignments that allow for the production of phenylalanine “substitutants” (a word they...
ROCKEFELLER UNIVERSITY PRESS IMAGE: PET IMAGING (RIGHT) SHOWS THE ACCUMULATION OF IRON IN METASTATIC TUMORS GROWING IN THE SPINE AND LIVER OF PATIENTS WITH PANCREATIC DUCTAL ADENOCARCINOMA. CREDIT: © 2022 JIANG ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. HTTPS://DOI.ORG/10.1084/JEM.20210739 Researchers at the University of California, San Francisco (UCSF), have discovered that cells carrying the...
POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH) IMAGE: A) SCHEMATIC DIAGRAM OF A REDOX-TRIGGERED SELF-IMMOLATIVE NITRIC OXIDE PRODRUG AND ITS APPLICATION (CONJUGATION WITH A CARRIER), AND THE PRINCIPLE OF REDOX-TRIGGERED SELF-IMMOLATIVE FRAGMENTATION. B) SCHEMATIC OF THE LYMPHATIC DELIVERY AND TREATMENT PROCESS OF REDUCTIVE NITRIC OXIDE PRODRUGS FOR THE TREATMENT OF METASTATIC CANCER. CREDIT: POSTECH Assassins...
by University of Montreal Graphical abstract. Credit: DOI: 10.1016/j.celrep.2021.110111 Awakening the immune system’s instinct for destroying cancer, using two molecules located on the surface of macrophages: that’s the promising avenue opening up from recent laboratory work of Dr. André Veillette. Director of the Molecular Oncology Research Unit of the Montreal Clinical Research Institute (IRCM) and...
by University of Michigan Credit: CC0 Public Domain When cancer cells metastasize, they morph, becoming missile-shaped in order to penetrate into other tissues throughout the body. In fact, to travel throughout the body, metastatic cancer cells must change their phenotypes—their physical characteristics. This change allows stationary, epithelial cells which compose the barriers of our organs...
by Osaka University Fig.1 Antisense oligonucleotide (ASO) targeting Arl4c inhibits pancreatic cancer metastasis. Credit: Akikazu Harada Pancreatic cancer is very aggressive and, unfortunately, has a poor prognosis with a 5-year survival of only 5%. Most deaths related to pancreatic cancer are due to metastasis, which occurs when the tumor invades other organs. Treatments to stop tumor...
ROCKEFELLER UNIVERSITY PRESS IMAGE: COMPARED WITH A CONTROL (LEFT PANELS), C26 TREATMENT (RIGHT PANELS) REDUCES THE NUMBER OF METASTATIC TUMORS IN THE LUNGS OF MICE INJECTED WITH HSNCC CELLS. CREDIT: © 2021 KHALIL ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. A new therapeutic approach prevents the growth of metastatic tumors in mice by...
by Keck School of Medicine of USC Credit: Pixabay/CC0 Public Domain Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy. To carry out these behaviors, each cancer cell uses its genes to make the needed molecules...
by Bob Yirka, Medical Xpress Credit: Pixabay/CC0 Public Domain A team of researchers working at the University of New Mexico Health Science Center has found some success in creating a cancer vaccine by coating cancer cells in silica and injecting them into test mice. In their paper published in the journal Nature Biomedical Engineering, the group...
