by University of California, Los Angeles Credit: CC0 Public Domain Scientists from the UCLA Jonsson Comprehensive Cancer Center have identified a key protein, transcription factor TAF12, that plays a critical role in the formation of a preinitiation complex, which consists of over one hundred proteins that are necessary for the transcription of protein-coding genes. The team...
MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA — Most of the tests that doctors use to diagnose cancer — such as mammography, colonoscopy, and CT scans — are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine. MIT engineers...
by Jesper Nylandsted, University of Copenhagen Fig. 1 Laser injury leads to ATG7-dependent formation of LC3-positive vesicles around the plasma membrane repair area. (A) MCF7 cells were injured by ablation laser in a medium with or without Ca2+. Mean ± SEM of normalized FM1-43 cytoplasmic dye levels, 11 cells per condition from three experiments, P <...
Cancer is a complex disease, and as such, there is not just a single way to tackle it. While cancer treatments are evolving towards personalized procedures, in most cases standard chemotherapy treatments are still required. In chemotherapy, platinum drugs such as cisplatin (approved 42 years ago by FDA) are used, killing both cancerous and healthy...
KUMAMOTO UNIVERSITY IMAGE: Top: The device is small enough to fit in the palm of your hand. Bottom left: The device filter is designed with slits allowing for deformation with fluid force. Bottom right: As blood flows through the device, the fluid force causes the slits to open, changing the shape of the filter and...
by Delthia Ricks , Medical Xpress Electron micrographs of hepatitis C virus purified from cell culture. The scale bar is 50 nanometers. Credit: Center for the Study of Hepatitis C, The Rockefeller University. The molecular world is full of surprises, and none more stunning than those occurring among the infinitesimal proteins that drive the activities...
by Barry Fitzgerald, Eindhoven University of Technology Credit: Eindhoven University of Technology An emerging nanomedicine cancer treatment involving the injection of tiny nanoparticles carrying compounds that can poison cancerous cells has many benefits. This so-called photodynamic therapy (PDT) is non-toxic and doesn’t involve invasive surgery. A team led by Jan van Hest from Eindhoven University of...
UNIVERSITY OF HELSINKI Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells promote their chances to form cancer. Typically, the accumulation of harmful cells is prevented by active competition between multiple stem cells in intestinal glands, called crypts. “The functioning of intestinal stem cells relies on growth...
by Carla K. Johnson This 1974 microscope image made available by the Centers for Disease Control and Prevention shows changes in cells indicative of adenocarcinoma of the prostate. In results released Thursday, June 3, 2021 by the American Society of Clinical Oncology, doctors are reporting improved survival in men with advanced prostate cancer from an...
COLD SPRING HARBOR LABORATORY Normal cells usually have multiple solutions for fixing problems. For example, when DNA becomes damaged, healthy white blood cells can use several different strategies to make repairs. But cancer cells may “put all their eggs in one basket,” getting rid of all backup plans and depending on just one pathway to...
