by University of Cambridge Graphical abstract. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI162129 A cancer drug currently in the final stages of clinical trials could offer hope for the treatment of a wide range of inflammatory diseases, including gout, heart failure, cardiomyopathy, and atrial fibrillation, say scientists at the University of Cambridge. In a study,...
By Paul McClure August 03, 2023 Researchers have developed an monoclonal antibody drug that targets the process that causes cancer cells to spread in the body Depositphotos Metastatic cancer accounts for up to 90% of all cancer deaths in the US annually. But with researchers developing a first-of-its-kind drug that inhibits the process by which cancer cells...
By Helen Floersh Jun 14, 2023 02:00 Cancer drug from Pfizer appears to stop aneurysm growth, opening door to nonsurgical treatment. Researchers found that a mutation in the gene PDGFRB was present throughout an aneurysm’s tissue layers, which helped explain the mechanics behind its formation. (Getty Images) About five of every 100 people have a...
by National Jewish Health Credit: Pixabay/CC0 Public Domain Researchers have shown that the medication saracatinib shows promise as a treatment for idiopathic pulmonary fibrosis (IPF). Saracatinib worked as well or better than two approved drugs at reducing tissue scarring in preclinical models of IPF according to the study published in the American Journal of Respiratory and...
PI3K is a protein that is part of a pathway that regulates cell growth, survival and metabolism — earning it the inscription of master regulator for cancer. However, while a number of PI3K inhibitor drugs have been approved since 2014, the class as a whole has dwindled, as it has been plagued by toxicity issues...
by University of British Columbia Effects of CSF1R inhibitors – and the absence of self-renewing resident macrophages – on muscle regeneration in mice. Credit: F. Babaeijandaghi, et al., Science Translational Medicine (2022) Researchers at the University of British Columbia’s School of Biomedical Engineering have discovered that an existing cancer drug could have potential as a treatment for muscular...
By MANSUR SHAHEEN U.S. DEPUTY HEALTH EDITOR FOR DAILYMAIL.COM PUBLISHED: 16:59 EDT, 6 June 2022 | UPDATED: 18:07 EDT, 6 June 2022 A new colorectal cancer drug has shocked researchers with how effective it is against the highly dangerous disease, as it virtually cured it in every member of a clinical trial. Dostarlimab, a monoclonal antibody drug, smashed expectations in...
by Karolinska Institutet Graphical abstract. Credit: EMBO reports (2022). DOI: 10.15252/embr.202154499 The repurposing of FDA-approved drugs for alternative diseases is a faster way of bringing new treatments into the clinic. Researchers at Karolinska Institutet in Sweden have repurposed a cancer drug for treatment of neuroinflammatory diseases such as multiple sclerosis. A novel drug carrier was also developed...
any cancer treatments are notoriously savage on the body. Drugs often attack both healthy cells and tumor cells, causing a plethora of side effects. Immunotherapies that help the immune system recognize and attack cancer cells are no different. Though they have prolonged the lives of countless patients, they work in only a subset of patients....
by Julia Evangelou Strait, Washington University School of Medicine in St. Louis An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, according to a new study in mice from Washington University School of Medicine in St. Louis. Shown are sections of liver from mice on...
