by Julia Evangelou Strait, Washington University School of Medicine in St. Louis An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, according to a new study in mice from Washington University School of Medicine in St. Louis. Shown are sections of liver from mice on...
by Institute of Cancer Research Credit: Institute of Cancer Research The first cancer patients are to receive doses of an innovative new drug that targets a master regulatory pathway in cells, as part of a new clinical trial. The drug, called NXP800, was discovered at The Institute of Cancer Research, London, and targets the pathway regulated...
by University College London Cancer cell during cell division. Credit: National Institutes of Health A therapeutic antibody developed by scientists at UCL has been shown to unblock and normalize blood vessels inside cancerous tumors, enabling the more effective delivery of targeted cancer treatments. The findings in mice, published in the journal Med, are the first to...
IMAGE: UPPER RIGHT: SCREENING COMPOUNDS IN THE “JUNKYARD OF CANCER DRUGS”, AKIN TO SIEVING THROUGH SAND, LOOKING FOR GOLD NUGGETS. KENPAULLONE WAS IDENTIFIED AS A PROMISING CANDIDATE OWING TO ITS ABILITY TO SWITCH ON THE KCC2 GENE, WHICH HAS BEEN PREDICTED TO ALLEVIATE CHRONIC PAIN. UPPER LEFT: INTRACTABLE CHRONIC PAIN IS A SERIOUS AND PRESSING...
by Trinity College Dublin Fig. 1: Tumoricidal activity of two non-homologous alpha-helical peptide–oleate complexes. a Ribbon representation of the crystallographically determined three-dimensional structure of human α-lactalbumin (PDB ID: 1B9O), indicating the alpha1 (blue), beta (green), and alpha2 (gray) domains. The calcium ion is not shown. b Far-UV circular dichroism spectra of synthetic alpha1 peptide, beta peptide,...
By Rich Haridy May 26, 2021 New research has found some species of gut bacteria can help minimize the negative effects of chemotherapy on the microbiome. A compelling new proof of concept study from researchers at Northwestern University has demonstrated how certain types of protective gut bacteria can help negate the damaging side effects of...
by University of Cambridge Credit: CC0 Public Domain Scientists have made a promising step towards developing a new drug for treating acute myeloid leukaemia, a rare blood disorder. In a study published today in Nature, Cambridge researchers report a new approach to cancer treatment that targets enzymes which play a key role in translating DNA into...
TOKYO UNIVERSITY OF SCIENCE The main culprit in cancer is healthy cells that have gone rogue and acquire the ability to divide uncontrollably. These cells acquire growth advantages over normal cells and manipulate their environment by altering the cellular pathways involved in growth and metabolism. Over the past few decades, various altered pathways and proteins...
By Pete Farley Plitidepsin was 27.5-fold more potent against SARS-CoV-2 than remdesivir, a drug that received FDA emergency use authorization in 2020 for the treatment of COVID-19, according to new research. Image by NIH Scientists at UC San Francisco’s Quantitative Bioscience Institute (QBI) and the Icahn School of Medicine at Mt. Sinai (ISMMS) in New York have shown that plitidepsin...
Upon entry into our cells, SARS-CoV-2 immediately gets to work replicating itself. The process is nothing short of impressive: A suite of enzymes and proteins work to copy the virus’s genetic material into thousands of more copies, wrapping each in proteins and lipids, and ultimately sending them bursting out of the cell-like confetti from a...
