by British Medical Journal Credit: CC0 Public DomainMany cancer drugs approved by the European Medicines Agency (EMA) between 1995 and 2020 lack proof of added benefit, particularly those approved through expedited (“fast track”) pathways, finds a study published by The BMJ. Despite pharmaceutical industry claims that high drug prices are needed to offset research and development...
by Mass General Brigham Credit: Pixabay/CC0 Public Domain Intratumoral therapy—in which cancer drugs are injected directly into tumors—is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection. A team of...
UNIVERSITY OF GOTHENBURG IMAGE: GABRIELLA CHAUCA STRAND CREDIT: ELIN LINDSTRÖM New cancer drugs are being launched at a rapid pace, before their long-term effectiveness for patients can be evaluated. Several years later, most of them still lack scientific evidence for actually increasing life expectancy or improving quality of life. This has been shown by a...
by University of Gothenburg Diseases targeted in the included trials. Credit: Clinical Drug Investigation (2023). DOI: 10.1007/s40261-023-01285-4 New cancer drugs are being launched rapidly before their long-term effectiveness for patients can be evaluated. Several years later, most of them still lack scientific evidence for increasing life expectancy or improving quality of life, a study at the University of...
RICE UNIVERSITY IMAGE: RICE UNIVERSITY SCIENTISTS HAVE ENLISTED WIDELY USED CANCER THERAPY SYSTEMS TO CONTROL GENE EXPRESSION IN MAMMALIAN CELLS, A FEAT OF SYNTHETIC BIOLOGY THAT COULD CHANGE HOW DISEASES ARE TREATED. CREDIT: PHOTO BY JEFF FITLOW/RICE UNIVERSITY HOUSTON – (Feb. 14, 2023) – Rice University scientists have enlisted widely used cancer therapy systems to...
by Agency for Science, Technology and Research (A*STAR), Singapore Graphical abstract. Credit: Nucleic Acids Research (2022). DOI: 10.1093/nar/gkac479 Scientists from A*STAR’s Institute of Molecular and Cell Biology (IMCB) and Genome Institute of Singapore (GIS), as well as the NUS Cancer Science Institute of Singapore (CSI Singapore), National Cancer Center Singapore (NCCS) and Nanyang Technological University (NTU), have...
By Nick Lavars June 07, 2022 A new technique has shown promise in delivering cancer drugs to cells Depositphotos Microbubbles and ultrasound might seem like an odd couple, but recently we’ve seen these two forces combine to great effect in the world of medicine. A newly developed treatment makes use of these tools to deliver...
by Perelman School of Medicine at the University of Pennsylvania Host ATF4 deletion inhibits tumor growth and extends survival.a, Top: loxP sites flank exons 2 and 3 of the Atf4 gene. Bottom: schematic of the tamoxifen treatment schedule. Tamoxifen (200 mg per kg body weight (BW) was given for 5 consecutive days by oral gavage. b, Box...
by Osaka University Fig.1 Diabetes incidence by cancer immunotherapy could be reduced by mesenchymal stem cell therapy. Credit: Diabetologia, CC0 Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes. Now, researchers from Osaka University have discovered that stem cell therapy may...
Two drugs may help treat advanced tumors, new research finds. luchschen/Getty Images Researchers have found two drugs to be safe and effective in treating individuals with advanced solid tumors. These medications, ATR inhibitor elimusertib and PARP inhibitor AZD5305, can block key mediators behind DNA damage response (DDR). In clinical studies, these drugs only induced “reversible...
