The scientists, working at the Department of Energy’s Oak Ridge National Laboratory, used neutron scattering at the Spallation Neutron Source and the High Flux Isotope Reactor to identify exact atomic-scale chemistry in serine hydroxymethyltransferase, or SHMT, a metabolic enzyme necessary for cell division. Drago and Kovalevsky examine the crystal Drago grew at ORNL to learn...
Tag: <span>cancer drugs</span>
Post
Significant proportion of cancer drugs lack proof of added benefit, finds study
by British Medical Journal Credit: CC0 Public DomainMany cancer drugs approved by the European Medicines Agency (EMA) between 1995 and 2020 lack proof of added benefit, particularly those approved through expedited (“fast track”) pathways, finds a study published by The BMJ. Despite pharmaceutical industry claims that high drug prices are needed to offset research and development...
Post
Researchers develop gel to deliver cancer drugs for solid tumors
by Mass General Brigham Credit: Pixabay/CC0 Public Domain Intratumoral therapy—in which cancer drugs are injected directly into tumors—is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection. A team of...
Post
Many expensive cancer drugs have unclear patient benefit
UNIVERSITY OF GOTHENBURG IMAGE: GABRIELLA CHAUCA STRAND CREDIT: ELIN LINDSTRÖM New cancer drugs are being launched at a rapid pace, before their long-term effectiveness for patients can be evaluated. Several years later, most of them still lack scientific evidence for actually increasing life expectancy or improving quality of life. This has been shown by a...
Post
Study shows many expensive cancer drugs have unclear patient benefit
by University of Gothenburg Diseases targeted in the included trials. Credit: Clinical Drug Investigation (2023). DOI: 10.1007/s40261-023-01285-4 New cancer drugs are being launched rapidly before their long-term effectiveness for patients can be evaluated. Several years later, most of them still lack scientific evidence for increasing life expectancy or improving quality of life, a study at the University of...
Post
Rice scientists reengineer cancer drugs to be more versatile
RICE UNIVERSITY IMAGE: RICE UNIVERSITY SCIENTISTS HAVE ENLISTED WIDELY USED CANCER THERAPY SYSTEMS TO CONTROL GENE EXPRESSION IN MAMMALIAN CELLS, A FEAT OF SYNTHETIC BIOLOGY THAT COULD CHANGE HOW DISEASES ARE TREATED. CREDIT: PHOTO BY JEFF FITLOW/RICE UNIVERSITY HOUSTON – (Feb. 14, 2023) – Rice University scientists have enlisted widely used cancer therapy systems to...
Post
New discovery in cancer progression paves way to cancer drugs with fewer side effects
by Agency for Science, Technology and Research (A*STAR), Singapore Graphical abstract. Credit: Nucleic Acids Research (2022). DOI: 10.1093/nar/gkac479 Scientists from A*STAR’s Institute of Molecular and Cell Biology (IMCB) and Genome Institute of Singapore (GIS), as well as the NUS Cancer Science Institute of Singapore (CSI Singapore), National Cancer Center Singapore (NCCS) and Nanyang Technological University (NTU), have...
Post
Bursting bubbles create cell openings for potent delivery of cancer drugs
By Nick Lavars June 07, 2022 A new technique has shown promise in delivering cancer drugs to cells Depositphotos Microbubbles and ultrasound might seem like an odd couple, but recently we’ve seen these two forces combine to great effect in the world of medicine. A newly developed treatment makes use of these tools to deliver...
Post
Stress protein in fibroblasts may be good target for future cancer drugs, study finds
by Perelman School of Medicine at the University of Pennsylvania Host ATF4 deletion inhibits tumor growth and extends survival.a, Top: loxP sites flank exons 2 and 3 of the Atf4 gene. Bottom: schematic of the tamoxifen treatment schedule. Tamoxifen (200 mg per kg body weight (BW) was given for 5 consecutive days by oral gavage. b, Box...
Post
Stem cell therapy protects against the side effects of cancer drugs
by Osaka University Fig.1 Diabetes incidence by cancer immunotherapy could be reduced by mesenchymal stem cell therapy. Credit: Diabetologia, CC0 Immune checkpoint inhibitors are widely used to treat a variety of cancers; however, one serious side effect is the onset of type 1 diabetes. Now, researchers from Osaka University have discovered that stem cell therapy may...