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Chemically ‘poisoned’ protein acts as a molecular switch to spur cancer formation
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Chemically ‘poisoned’ protein acts as a molecular switch to spur cancer formation

by The Scripps Research Institute Researchers discovered that when the protein DNMT3B becomes S-nitrosylated in the presence of nitric oxide (NO), cancer-related genes become activated, leading to the proliferation of tumor cells. Credit: Scripps Research Scientists at Scripps Research, with collaborators in Japan, have discovered how a “poisoned” form of a protein could set off a cascade of...

Uncovering how injury to the pancreas impacts cancer formation
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Uncovering how injury to the pancreas impacts cancer formation

VANDERBILT UNIVERSITY IMAGE: PANCREATIC ACINAR CELLS FORM A HETEROGENEOUS POPULATION OF NEW CELL TYPES IN RESPONSE TO INJURY WITH THE POTENTIAL TO LIMIT OR DRIVE DISEASE. ACINAR-DERIVED CLONES LABELED IN RED AND GREEN. CREDIT: DELGIORNO, ET. AL. The Idea Pioneering research from scientists at the Vanderbilt University School of Medicine Basic Sciences and the Salk...