by Leiden University Tumor-infiltrating Vδ1 and Vδ3 T cell subsets display hallmarks of cytotoxic activity in MMR-d colon cancers. a, UMAP embedding showing the clustering of γδ T cells (n = 4,442) isolated from MMR-d colon cancers (n = 5) analyzed using scRNA-seq. The colors represent the TCR Vδ chain usage. Dots represent single cells. b, The frequencies of...
by UNC Lineberger Comprehensive Cancer Center Credit: Unsplash/CC0 Public Domain Researchers at UNC Lineberger Comprehensive Cancer Center have found a possible way to overcome barriers that block effective anti-cancer immune responses, thereby opening the potential for more effective immunotherapies in people. The findings are published in Nature. An unfavorable immune environment immediately surrounding a tumor cell...
by Jeremy Thomas, Lawrence Livermore National Laboratory Left: This image shows tumor and immune cells (blue for all nuclei) grown on Collagen IV. The orange spots show T-cells (immune cells) in the process of dying. Right: This image depicts tumor cells combined with living T-cells growing on a scaffolding of proteins. Credit: Monica Moya/LLNL Lawrence...
WEILL CORNELL MEDICINE IMAGE: ART1 (IN GREEN) EXPRESSION IN TUMOR TISSUE FROM A LUNG CANCER PATIENT. CREDIT: SUMIT MUKHERJEE Tumors can use an enzyme called ART1 to thwart antitumor immune cells, making the enzyme a promising new target for immunity-boosting cancer treatments, according to a study from researchers at Weill Cornell Medicine and Albert Einstein College...
