by Johns Hopkins University School of Medicine Novel cancer immunotherapy approach inverts a missing gene copy into an immune cell-activating signal. Credit: Elizabeth Cook Researchers developed a prototype for a new cancer immunotherapy that uses engineered T cells to target a genetic alteration common among all cancers. The approach, which stimulates an immune response against cells that...
LUDWIG INSTITUTE FOR CANCER RESEARCH IMAGE: TAHA MERGHOUB AND JEDD WOLCHOK OF THE LUDWIG CENTER AT MEMORIAL SLOAN KETTERING CANCER CENTER (MSK) AND FORMER POSTDOC ROBERTA ZAPPASODI CREDIT: LUDWIG CANCER RESEARCH FEBRUARY 15, 2021, NEW YORK – A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known...
AMERICAN CHEMICAL SOCIETY Messenger RNA (mRNA) vaccines to prevent COVID-19 have made headlines around the world recently, but scientists have also been working on mRNA vaccines to treat or prevent other diseases, including some forms of cancer. Now, researchers reporting in ACS’ Nano Lettershave developed a hydrogel that, when injected into mice with melanoma, slowly released...
NANJING UNIVERSITY SCHOOL OF LIFE SCIENCES IMAGE: SMECTITE MICROSPHERES SPECIFICALLY SUPPORT THE TYPICAL PROBIOTICS, L. ACIDOPHILUS AND B. LONGUM TO FORM BIOFILMS ON THE SURFACE. CREDIT: LEI DONG, NANJING UNIVERSITY Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the...
UNIVERSITY OF CALIFORNIA – SAN FRANCISCO For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond. A new study finds that inherited genetic...
by University of Pittsburgh Credit: CC0 Public Domain Researchers at UPMC Hillman Cancer Center and the National Cancer Institute (NCI) demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy—which has a failure rate of 40% for this type of cancer—into patients who do. The results of this proof-of-principle phase...
by Catherine Williams, Emory University Orange represents tumor cells displaying the HPV antigen p16, while green represents B cells with the arrows indicating germinal center-like structures. Immunotherapies have transformed the treatment of several types of cancer over the last decade. Yet they focus on reactivating one arm of the immune system: cytotoxic T cells, which sniff...
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE New York, NY (October 29, 2020) — A groundbreaking new type of cancer immunotherapy developed at the Icahn School of Medicine at Mount Sinai trains the innate immune system to help it eliminate tumor cells through the use of nanobiologics, tiny materials bioengineered from natural...
by University of Tsukuba Using the body’s immune system to fight cancer has great potential, but can also bring serious side effects, including itchy and painful skin reactions. But now, researchers from Japan have found how these skin reactions happen, potentially leading to a way to prevent them. In a study published this month in Communications Biology, researchers from the University...
by Ludwig Institute for Cancer Research A Ludwig Cancer Research study has uncovered a mechanism by which the tumor’s harsh internal environment sabotages T lymphocytes, leading cellular agents of the anticancer immune response. Reported in Nature Immunology, the study describes how a variety of stressors prevalent in the tumor microenvironment disrupt the power generators, or mitochondria, of tumor-infiltrating T lymphocytes (TILs),...
