The development of immunotherapy, which mobilizes the body’s own immune system to destroy cancer cells, is one of the greatest advances in cancer treatment, but immunotherapy can cause harm to healthy tissue in some patients. Researchers at UT Southwestern have identified blood-based biomarkers that may help identify those patients at greatest risk of developing autoimmune...
Tag: <span>Cancer Immunotherapy</span>
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Immunotherapy Complete Response Data Suggest Metastatic Melanoma Cures
This is Dr Jeffrey Weber. I am a medical oncologist at the Laura and Isaac Perlmutter Cancer Center at New York University Langone Health in New York City. Today we will be talking about a very interesting article that appeared several months ago in the Journal of Clinical Oncology,[1] which I think sheds light on...
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Discovery could lead to higher immunotherapy response rates for bladder cancer patients
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE (New York, NY – August 29, 2018) — Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint...
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Woman’s late-stage breast cancer cured by immunotherapy treatment that supercharged her own cells to fight the disease in a world first
Immunotherapy enhances a patient’s own T cells to make them fight cancer better Doctors at the National Institutes of Health have cured a woman of her breast cancer using the experimental new treatment A woman has been cured of her breast cancer by a revolutionary treatment that used supercharged versions of her own immunity cells...
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The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy
The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we...
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Researchers Build a Cancer Immunotherapy Without Immune Cells
Conceptual illustration of a designer cell sensing a target cell Engineering an immune cell to recognize and kill a cancer cell is the key to chimeric antigen receptor (CAR) T-cell therapy, but modified immune cells also have the potential to cause problems for patients. One such complication, cytokine release syndrome, is an overreaction of the immune...
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Cancer immunotherapy may work better in patients with specific genes
Cancer cells arise when DNA is mutated, and these cells should be recognized as “foreign” by the immune system. However, cancer cells have found ways to evade detection by the immune system. New drugs called immune checkpoint inhibitors can restore the immune system’s recognition of cancer cells and have led to dramatic responses in a...
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Scientists discover possible master switch for programming cancer immunotherapy
Study authors Adam Getzler, Dapeng Wang and Matthew Pipkin of The Scripps Research Institute collaborated with scientists at the University of California, San Diego. During infection or tumor growth, a type of specialized white blood cells called CD8+ T cells rapidly multiply within the spleen and lymph nodes and acquire the ability to kill...
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Combination immunotherapy targets cancer resistance
Image shows infiltration of transplanted human cancer cells (yellow/orange) by two myeloid cell subsets (red and green) in a mouse model treated with combination immunotherapy. Cancer immunotherapy drugs have had notable but limited success because in many cases, tumors develop resistance to treatment. But researchers at Yale and Stanford have identified an experimental antibody...
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Genome editing enhances T-cells for cancer immunotherapy
Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Researchers at Cardiff University have found a way to boost the cancer-destroying ability of the immune system’s T-cells, offering new hope in the fight against a wide range of cancers. Using CRISPR genome...