Tumor cells secrete lactate (blue dots) that makes contact with naïve T cells and contributes to FIP200 expression that disables the balance between pro-apoptotic and anti-apoptotic gene expression in the cells. The immune cells that are trained to fight off the body’s invaders can become defective. It’s what allows cancer to develop. So most...
Tag: <span>Cancer Immunotherapy</span>
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Cancer immunotherapy uses melanin against melanoma
Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based on early experiments done in a mouse model. The technique is applied via a transdermal patch (shown here) and is made more …more Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based...
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‘Synthetic gene circuit’ may improve effectiveness of cancer immunotherapy
Synthetic gene circuits that only trigger powerful, tumor-specific immune responses when they detect certain disease markers may help immunotherapies to fight cancer more effectively, according to a new study. Researchers from the Massachusetts Institute of Technology (MIT) in Cambridge suggest that their artificial DNA-encoded circuits may help to overcome some of the problems that have...
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Types of Immunotherapy Cancer Patients Need to Understand
Immunotherapy is an FDA-approved treatment for cancer that has significantly improved outcomes for patients. Immunotherapy is actually an umbrella term for different kinds of treatment, according to oncologist Melissa Wilson, MD, PhD, of the NYU Langone Medical Center. Four commonly used types of immunotherapy include antibodies, vaccines, cytokines, and checkpoint inhibitors. Antibodies are an active...
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The Types of Cancer that Immunotherapy Can Help Treat
Immunotherapy is a breakthrough cancer treatment that harnesses your own body’s immune system to identify and destroy cancer cells. When doctors talk about immunotherapy as a cancer treatment, they are actually referring to different kinds treatments that fall under the umbrella of immunotherapy, such as antibodies, vaccines, cytokines, and checkpoint inhibitors. Each immunotherapy treatment affects...
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Cancer immunotherapy may get a boost by disabling specific T cells
Scanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Cancer immunotherapy drugs only work for a minority of patients, but a generic drug now used to increase blood flow may be able to improve those odds, a study by Columbia University Medical...
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Concurrent treatment with OX40- and PD1-targeted cancer immunotherapies may be detrimental
Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice. “While immune checkpoint inhibitors, such as anti-PD1 and anti-CTLA4, are already in clinics and are used mainly as single agents, there are currently almost a thousand clinical...
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Boosting immune cell memory to improve vaccines and cancer immunotherapy
Vaccines and cancer immunotherapies do essentially the same thing: They boost a person’s immune system, better enabling it to fight an offender, be it microbe or malignancy. Both approaches focus on CD8+ T cells, a type of immune cell that can either kill immediately or commit the offender to “memory,” providing long-term protection. In mouse...
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Cancer Immunotherapy: Fighting fire with fire
We, as humans, tend to idealize that which is bigger, better, faster, and stronger. It is in our nature to strive towards the best. To improve. To win. Indeed, the penetrance of this mentality reaches to our very core, even to the individual cells of which we are composed. A prime example of this: cancer....
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DNA sensor plays critical role in cancer immunotherapy via response to unexpected DNA form
UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert system. That chemical alarm via the molecule cGAS is an important immune-system sensor for DNA that is in the soupy interior of cells, the cytosol, where DNA should...