We, as humans, tend to idealize that which is bigger, better, faster, and stronger. It is in our nature to strive towards the best. To improve. To win. Indeed, the penetrance of this mentality reaches to our very core, even to the individual cells of which we are composed. A prime example of this: cancer....
Tag: <span>Cancer Immunotherapy</span>
Post
DNA sensor plays critical role in cancer immunotherapy via response to unexpected DNA form
UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert system. That chemical alarm via the molecule cGAS is an important immune-system sensor for DNA that is in the soupy interior of cells, the cytosol, where DNA should...
Post
Identification of essential genes for cancer immunotherapy
Abstract Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic loss-of-function mutations involved in resistance to these therapies, by using a genome-scale CRISPR–Cas9 library that consisted of around 123,000 single-guide RNAs, and profiled genes whose loss in tumour cells impaired the...
Post
New study identifies essential genes for cancer immunotherapy
A new study identifies genes that are necessary in cancer cells for immunotherapy to work, addressing the problem of why some tumors don’t respond to immunotherapy or respond initially but then stop as tumor cells develop resistance to immunotherapy. The study, from the National Cancer Institute (NCI), was led by Nicholas Restifo, M.D., a senior...
Post
A new T-cell population for cancer immunotherapy
Scientists at the University of Basel in Switzerland have, for the first time, described a new T cell population that can recognize and kill tumor cells. The open access journal eLife has published the results. T lymphocytes (short T cells) are a special type of cells that recognize germs and protect our body from infections. Their second important...
Post
Cancer immunotherapy may work in unexpected way
Researchers have found that a cancer therapy may prompt a type of immune cell called a macrophage (illustrated above) to attack cancer. Antibodies to the proteins PD-1 and PD-L1 have been shown to fight cancer by unleashing the body’s T cells, a type of immune cell. Now, researchers at the Stanford University School of...
Post
Antibody for fighting cancer emerges
Killer T cells surround a cancer cell. While studying the underpinnings of multiple sclerosis, investigators at Brigham and Women’s Hospital came across important clues for how to treat a very different disease: cancer. In a paper published in Science Immunology, a group of researchers led by neurologist Howard Weiner, MD, describe an antibody that can...