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In the lab: T cells artificially endowed with 2 cancer-seeking receptors aim to be an elite army of cancer killers
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In the lab: T cells artificially endowed with 2 cancer-seeking receptors aim to be an elite army of cancer killers

by Delthia Ricks, Medical Xpress Figure S1. Design of chimeric antigen receptor (CAR) and chimeric costimulatory receptor (CCR) constructs and expression of CAR, CCR, and CD38 on T cells. (A) Schematic diagrams of the vectors used for CARs and CCRs are shown. SP, signal peptide; P2A, “self-cleaving” 2A peptide; IC, intracellular domain; TM, transmembrane domain....

Right program could turn immune cells into cancer killers
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Right program could turn immune cells into cancer killers

by Amy Mone,  Johns Hopkins University A tumor-specific T cell engages with a tumor cell. Bystander T cells do not engage with the tumor. Credit: PNAS Dec. 10, 2002, Copyright (2002) National Academy of Sciences Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program”...