by Delthia Ricks, Medical Xpress Figure S1. Design of chimeric antigen receptor (CAR) and chimeric costimulatory receptor (CCR) constructs and expression of CAR, CCR, and CD38 on T cells. (A) Schematic diagrams of the vectors used for CARs and CCRs are shown. SP, signal peptide; P2A, “self-cleaving” 2A peptide; IC, intracellular domain; TM, transmembrane domain....
Tag: <span>cancer killers</span>
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Right program could turn immune cells into cancer killers
by Amy Mone, Johns Hopkins University A tumor-specific T cell engages with a tumor cell. Bystander T cells do not engage with the tumor. Credit: PNAS Dec. 10, 2002, Copyright (2002) National Academy of Sciences Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different “program”...