by Hokkaido University (Top) Cancer stem cells produce interleukin-6 (IL-6), which induces senescence in macrophages (Mφ). In turn, these produce arginase-1 and inactivate T cells. As a result, cancer cells are not killed by immune system cells, leading to tumor formation. (Bottom) Non-cancer stem cells do not produce IL-6. Macrophages do not age and T cells...
by Rockefeller University TGF beta signaling (red) is one way that the environment causes cancer stem cells at the stroma-tumor border (green) to become invasive. Living cells are dyed blue. Credit: Shaopeng Yuan What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the...
HOKKAIDO UNIVERSITY A hydrogel, a type of soft matter, developed at Hokkaido University successfully reverted cancer cells back to cancer stem cells within 24 hours, in six different human cancer types. This could lead to the development of anti-cancer stem cell drugs and personalized medicines. An innovative hydrogel – called a double network (DN) gel...
By Michael Irving January 20, 2021 Multiple myeloma attacks the white blood cells, but a new treatment may help ezumeimages/Depositphotos VIEW 2 IMAGES Like weeds that grow back if you don’t remove the roots, cancer can keep returning thanks to lurking stem cells. Now, researchers have developed a “designer” DNA segment that can eradicate these cancer stem...
by Tabea Kemna, Karolinska Institutet In an interdisciplinary study combining stem cell biology and tumor biology, researchers from Karolinska Institutet (as well as Uppsala and Lund University, together with researchers in Canada, Germany and France), have succeeded in creating a new type of stem cell model for studies on cancer of the brain. The study...
Lab experiments show that the chemical compound damsin found in the plant Ambrosia arborescens inhibits the growth and spread of cancer stem cells. The similar but synthetically produced ambrosin has the same positive effect, according to researchers at Lund University and University Major of San Andrés in La Paz, Bolivia. The plant Ambrosia arborescens grows...
Researchers from Princeton University’s Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. Above, the microscopic image shows …more Researchers from Princeton University’s Department of Molecular Biology have identified a small RNA molecule that helps maintain the activity of...
Cancer is currently one of the top killers worldwide, and the number of cancer cases is only expected to rise. Although there are a number of therapies available, most of them are toxic and cause serious side effects. New research examines the impact of the natural vitamin C on cancer cell growth. In a recent...
WEST LAFAYETTE, Ind. — Researchers have discovered a metabolic signature critical for the functioning of “cancer stem cells” that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting tumor growth. “The cancer stem cells are resistant to conventional therapies and are responsible for tumor relapse after...
