by University of Freiburg Only within the past few years has malignant melanoma been treatable with immunotherapy. However, in every second patient, strong autoimmune reactions such as skin rash or diarrhea occur after immunotherapy. Researchers from the Medical Center—University of Freiburg and Swiss colleagues have now shown that these reactions can be stopped with a...
Tag: <span>Cancer Therapy</span>
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Discovery of new T-cell raises prospect of ‘universal’ cancer therapy
by Cardiff University Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a “one-size-fits-all” cancer therapy. T-cell therapies for cancer—where immune cellsare removed, modified and returned to the patient’s blood to seek and destroy cancer cells—are the latest paradigm in cancer treatments. The most widely used therapy, known...
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Flipping the script on novel cancer therapy leads to insights into lupus
YALE UNIVERSITY In the last decade, scientists discovered that blocking a key regulator of the immune system helped unleash the body’s natural defenses against several forms of cancer, opening up a new era of cancer immunotherapy. Now Yale scientists have essentially flipped this script and found that when impaired a molecularly similar regulator can cause...
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Genetic diversity facilitates cancer therapy
by Max Planck Society The constant battle against infectious pathogens has had a decisive influence on the human immune system over the course of our evolution. A key role in our adaptation to pathogens is played by HLA molecules. These proteins activate the immune system by presenting it with fragments of pathogens that have entered...
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Scientists have identified the presence of cancer-suppressing cells in pancreatic cancer
by Nagoya University A research team led by Nagoya University has revealed that cells containing a protein called Meflin have a role in restraining the progression of pancreatic cancer, a type of cancer that is hard to treat with traditional anti-cancer drugs. The team has also shown that cancer progression can be limited by artificially...
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Study finds increased risk of cancer death following treatment for hyperthyroidism
by National Cancer Institute Findings from a study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer. The study, led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, was published July...
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Anti-CD47 cancer therapy safe, shows promise in small clinical trial
A novel immunotherapy appears safe for use in patients with a type of blood cancer called non-Hodgkin’s lymphoma, according to a phase-1 multicenter clinical trial led by a researcher at the Stanford University School of Medicine. Although some patients showed signs of a transitory anemia or reactions at the injection site, there were few other...
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Cyclic peptides for cancer therapy and prognosis assessment
The glucose-regulated protein 78 kDa (known as GRP78) is emerging as a target for cancer therapy and a biomarker for cancer prognosis. It is usually produced in greater quantities in cells that are under stress conditions. In many types of cancers, GRP78 protein has been observed to be produced in abnormally large quantities and it tends...
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The bacteria in your gut could help determine if a cancer therapy will work
Why does cancer immunotherapy work for some patients, but not others? Gut biodiversity could play a decisive role, two new studies in Science suggest. A lush microbiome populated with “good bacteria” can boost the power of the treatments, one paper found. On the other hand, certain immunotherapies were less effective in patients who were taking...
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Bionic thymus: Artificial organ for pumping T cells for Cancer Treatment
Researchers have successfully used an artificial thymus to turn blood stem cells into T cells. The UCLA researchers have created an artificial organoid as a useful tool in reducing the time and cost of T cell immunotherapy for patients with a low count of WBC’s. Thymus– the organ located near the heart makes T cells...