by CU Anschutz Medical Campus ENI ablates the immune response to combined radiation and immunotherapy. A Schematic of the experimental design for gross tumor irradiation with or without elective nodal irradiation (ENI). Mice were implanted both in the buccal and in the flank on day 0 post-implantation (DPI). Stereotactic body irradiation (SBRT) was given when...
by Josh Barney, University of Virginia Overview of KSTAR algorithm. First, we heuristically prune dense and highly overlapping weighted kinase-substrate prediction graphs from NetworKIN into many sparse, binary graphs. Statistical enrichment is calculated for an experiment that has a defined set of phosphorylation sites for every kinase across all networks using a hypergeometric distribution. We...
by University of Gothenburg Chandrasekhar Kanduri and Meena Kanduri, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg. Credit: Elin Lindström Researchers at the University of Gothenburg have identified a previously unknown mechanism controlling tumor growth in cultured cells and mice. This discovery may potentially enable future development of new drugs against a range...
by Catherine Graham, Johns Hopkins University Overview of workflow for assessing drug response from cancer cells. (a) Schematic workflow for directly assaying diseased cells from patient liquid biopsy samples for subsequent drug combination screening. Cell-trapping PDMS microfluidic chambers (turquoise) and Au electrode arrays (gold) of the assembled device allow cell purification from blood and subsequent...
The most common and the most effective (for now) cancer treatments – chemotherapy and radiotherapy – are also quite toxic. They damage healthy cells as well as cancer cells and cause tremendous side effects. Now a new study at the Newcastle University found that a one-off simple treatment could potentially prevent devastating consequences of cancer...
by University of Birmingham A double stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0 A new way in which cancer cells can repair DNA damage has been discovered by researchers at the University of Birmingham. These new findings shed new light on how cancer cells react to chemotherapy and radiotherapy, and also uncover a new...
by Rachel Rose, Texas A&M University The small device is designed to enable more individualized application of light dosing and photodynamic therapy. Credit: Justin Baetge/Texas A&M Engineering For those diagnosed with colorectal cancer, surgery has been the only option that offers a solution. Unfortunately, surgery is frequently complicated by disease recurrence at the site of...
by Stanford University As shown in this demonstration, the hydrogel can be easily injected through a needle and then rapidly self-heals after injection to form a solid-like gel. The needle in this image is a 21-gauge needle, a relevant size for human injection. Credit: Abigail K. Grosskopf One cutting-edge cancer treatment exciting researchers today involves...
EXPERIMENTAL BIOLOGY Philadelphia (April 4, 2022) – A study conducted in rats suggests that taking vitamin C may help to counteract the muscle atrophy that is a common side effect of the chemotherapy drug doxorubicin. Although clinical studies would be needed to determine the safety and effectiveness of taking vitamin C during doxorubicin treatment, the findings...
by Georgia Institute of Technology Sensing T cell killing of tumor cells by antibody–GzmB sensor conjugates. Credit: Nature Biomedical Engineering (2022). DOI: 10.1038/s41551-022-00852-y Immune checkpoint blockade (ICB) inhibitors have transformed the treatment of cancer and have become the frontline therapy for a broad range of malignancies. It’s because they work better than the previous standard of care....
