by Anna Björklund, Identification of a conformational switch in c-MYC. a Overview of the MD strategy employed to identify regions that exhibit probe-induced conformational changes. b Normalized frequency distribution of Rg computed from the ensemble of structures generated from explicit solvent MD simulations in water (black) and water + benzene (red) for all nine c-MYC...
By Paul McClure Researchers have added an active Rac2 protein to macrophages, causing them to cannibalize other immune cells Depositphotos Following a trail of evidence that started with a study of fruit flies nearly 25 years ago, researchers have found adding a hyperactive form of the protein Rac2 to macrophages, immune cells that eat pathogens, causes...
by Cold Spring Harbor Laboratory Two looks at mouse tumors. Left: staining by the Cold Spring Harbor Laboratory Animal & Tissue Imaging Shared Resource. Right: segmenting by Dominik Loiero in the lab of University of Zurich Assistant Professor Viktor Koelzer. The red segments on the right are cancer cells. Credit: Janowitz lab/Cold Spring Harbor Laboratory Immunotherapy...
AMERICAN INSTITUTE OF PHYSICS IMAGE: PLASMA-ACTIVATED MEDIUM FOR CANCER TREATMENT. CREDIT: HE CHENG, JINGYI LUO, KE SONG, FENG ZHAO, DAWEI LIU, LANLAN NIE, AND XINPEI LU WASHINGTON, June 28, 2022 – Chinese researchers may have found a new approach to treat cancer by using a plasma treatment to induce apoptosis, the death of cancer cells,...
A protein called CDC7, long thought to play an essential role early in the cell division process, is in fact replaceable by another protein called CDK1, according to a study by investigators at Weill Cornell Medicine and the Dana Farber Cancer Institute. The finding represents a fundamental advance in cell biology and may lead to new cancer therapies...
by National Institutes of Health Credit: CC0 Public Domain Existing and emerging cancer drugs could be repurposed as therapies to be tested in clinical trials for people at genetic risk of Alzheimer’s disease, according to a new study published in Science Advances. Research combining analysis of brain protein alterations in these individuals as well as laboratory...
by Karolinska Institutet Fig. 1 Elevated eIF4A3 expression in cancer is correlated with a high RiBi rate and poor prognosis. (A) Representative GENT2 (Gene Expression database of Normal and Tumor tissues 2)-derived comparison of eIF4A3 mRNA levels in various cancer types and their normal counterpart tissues (****P < 0.001). (B) Correlation of eIF4A3 mRNA expression levels...
UNIVERSITY HEALTH NETWORK IMAGE: DR. STEPHANIE XIE, AFFILIATE SCIENTIST, PRINCESS MARGARET CANCER CENTRE, UNIVERSITY HEALTH NETWORK. CREDIT: UHN Princess Margaret Cancer Centre researchers have made new findings that provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers. The team...
Using Argonne National Laboratory’s Advanced Photon Source, researchers have determined the structure of an enzyme that plays a key role in the spread of cancer cells. Chances are, every one of us has been affected by cancer in one way or another. Unlike some other deadly diseases, cancer can take many forms inside the human...
by University Health Network Credit: CC0 Public Domain The impact of deploying Artificial Intelligence (AI) for radiation cancer therapy in a real-world clinical setting has been tested by Princess Margaret researchers in a unique study involving physicians and their patients. A team of researchers directly compared physician evaluations of radiation treatments generated by an AI machine learning (ML) algorithm to conventional radiation...
