by Medical University of Vienna Computer-rendered image showing T cells (red) interacting with monocytes (yellow) and dendritic cells (blue) in the tumor microenvironment. These interactions help T cells to fully mature and effectively target and kill cancer cells. The scale bar (white) represents 10 micrometers (µm), indicating the size of the tumor regions shown. Credit: Obenauf...
Tag: <span>Cancer</span>
Post
Cancers grow uniformly throughout their mass
New research challenges the idea that tumors are ‘two-speed’ entitiesPeer-Reviewed Publication Center for Genomic Regulation image: Computer simulation showing how cells sharing the same type of mutation can either group closely together in one area of the tumour (shown in blue) or be spread out across different parts of the tumour (shown in red).view more Credit:...
Post
New insights show ASCL1’s role in neuroendocrine prostate cancer, an aggressive and treatment-resistant type
by Jim Stallard, Memorial Sloan Kettering Cancer Center Molecular characterization of PtPM and RPM primary prostate tumor transplants demonstrates emergence of neuroendocrine carcinoma marker expression. Credit: Nature Cancer (2024). DOI: 10.1038/s43018-024-00838-6 A scientist whose discoveries about prostate cancer have led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate...
Post
What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?
by Sathana Dushyanthen and David Kok, The Conversation Comparison of differences between traditional radiotherapy and stereotactic radiotherapy. Credit: Precision Radiation Oncology Prostate cancer is Australia’s most commonly diagnosed cancer. One in six men will be diagnosed by the time they turn 85. Cancers are abnormal groups of cells that grow uncontrollably and start invading neighboring sites. They can also spread to...
Post
Regulations of m6A and other RNA modifications and their roles in cancer
by Frontiers Journals Credit: Frontiers of Medicine (2024). DOI: 10.1007/s11684-024-1064-8 Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications. A comprehensive review published in Frontiers of Medicine reveals the significant role of various RNA modifications in cancer development and progression. The review particularly focuses...
Post
ACOG Updates Breast Cancer Screening Guidelines
The American College of Obstetricians and Gynecologists (ACOG) has updated its breast cancer screening guidelines, recommending that individuals at an average risk for breast cancer initiate mammography screening at age 40. This change reflects evolving evidence that starting earlier screening yields greater net benefits in reducing breast cancer mortality, particularly for certain racial groups with higher...
Post
New CAR-T cells offer on-demand control for cancer treatment
Credit: Pixabay/CC0 Public Domain Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells—a type of cancer immunotherapy—that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs. The design and preclinical evaluation of the CAR-T cells, led by Melita Irving and Greta...
Post
Understanding the maturation of white blood cells to find new therapies against lymphoblastic leukaemia
Josep Carreras Leukaemia Research Institute image: The Chromatin biology laboratory, led by Dr. Alejandro Vaquero, from the Josep Carreras Leukaemia Research Institute Credit: Josep Carreras Leukaemia Research Institute Over four hundred people, 80% of them being children under 14 years old, will be diagnosed with B-cell Acute Lymphoblastic Leukaemia (B-ALL) next year in Spain, according...
Post
Next-gen cell-penetrating antibodies for tumor targeting and RAD51 inhibition
“Overall, the data presented in this study affirm that humanizing 3E10 preserves its crucial biological properties essential for therapeutic efficacy.” Impact Journals LLC image: Figure 1: 3E10 humanization and heavy and light chain variant screening. (A) Diagram of the 3E10 antibody engineering process. The original murine wild-type 3E10 was modified to contain a human IgG1 Fc...
Post
How cancer cells may be using ribosomes to hide from the immune system
A ribosome, its different parts depicted in different colors. Ribosomes are the protein factories of our body’s cells. Credit: Netherlands Cancer Institute The protein factories of our cells are much more diverse than we thought they were. Scientists from the Netherlands Cancer Institute have now shown that cancer cells can use these ribosomes to boost...