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Small-molecule drug shows potential for hard to treat cancers
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Small-molecule drug shows potential for hard to treat cancers

September 23, 2024 by University of Dundee Credit: Unsplash/CC0 Public DomainExperts from the University of of Dundee’s Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a “protein degrader.” KRAS is the most mutated gene in cancer with mutations occurring in 17%–25% of all cancers, affecting millions...

ESMO: Combination therapy reduced agitated delirium in patients with advanced cancers
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ESMO: Combination therapy reduced agitated delirium in patients with advanced cancers

September 15, 2024 by University of Texas M. D. Anderson Cancer Center Credit: Unsplash/CC0 Public DomainTreatment with a combination of haloperidol and lorazepam reduced symptoms of agitated delirium, a common end-of-life condition for patients with advanced cancers, compared with haloperidol alone, according to a new study led by researchers at The University of Texas MD...

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Study identifies promising target for treating inflammatory bowel disease and colitis-induced colorectal cancers

by Will Cushman, University of Wisconsin-Madison This image shows the effect of pro-inflammatory cytokines on the growth of a mouse intestinal organoid. Intestinal stem cells (red) are indicative of inflammation and Ki67 proteins (green) are associated with tumors. Credit: Ting FuInflammation in the gut can trigger a doom loop of sorts. The condition messes with the...

Vaccine demonstrates potential in delaying relapse of KRAS-mutated pancreatic and colorectal cancers
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Vaccine demonstrates potential in delaying relapse of KRAS-mutated pancreatic and colorectal cancers

by University of Texas M. D. Anderson Cancer Center Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer InstituteA vaccine has shown potential to prevent relapse of KRAS-mutated pancreatic and colorectal cancers for patients who had previously undergone surgery, according to a Phase I trial led by researchers at The...

Discovery unlocks potential new arsenal to target leukemia and other cancers
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Discovery unlocks potential new arsenal to target leukemia and other cancers

by QIMR Berghofer Integrative analysis of samples from patients with AML. a, Unsupervised hierarchical clustering analysis on the expression of 300 transcripts with the greatest variance-to-mean ratios among 30 individual AMLs from our repository that can successfully generate AML PDX. MLD, multi-lineage dysplasia; MDS, myelodysplastic syndromes; MLL, mixed-lineage leukemia; NOS, not otherwise specified. b, Key...

Completely new mechanism behind some cancers discovered
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Completely new mechanism behind some cancers discovered

By Michael Irving May 09, 2023 Scientists have discovered a new cause of cancer – a mutation in a specific gene that interferes with a cellular cleanup process Depositphotos Cancer can be the end result of a wide range of things that go wrong, and understanding how is key to prevention and treatment. Now, scientists...

New AI Tool Predicts Cancers Better, May Catch Them Far Earlier
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New AI Tool Predicts Cancers Better, May Catch Them Far Earlier

By Hank Berrien•May 1, 2023  Peter Dazeley/GettyImages A new study indicates that an artificial intelligence tool can tremendously improve predictions of whether a nodule will develop cancer, thereby helping identify cancer much earlier in deadly diseases such as lung cancer. Experts at the Royal Marsden NHS foundation trust, the Institute of Cancer Research, London, and Imperial...

Research reveals why cancers stop responding to kinase-blocking drugs and come back stronger
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Research reveals why cancers stop responding to kinase-blocking drugs and come back stronger

by New York University Structure of the FGFR kinase showing the locations of the gatekeeper residue in blue, hydrophobic spine in yellow, and ATP in cyan. Most drugs bind to the kinase in the same pocket as ATP. Credit: Traaseth Lab/NYU More than 70 FDA-approved cancer drugs are kinase inhibitors, which work by blocking kinases—enzymes that...

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Screening Tests Diagnose About 14% of All Cancers

Roxanne Nelson, RN, BSN December 20, 2022 Currently, guidelines recommend screening for only four types of cancer, and adherence to the guidelines is often low. Nnevertheless, screening tests lead to diagnoses of about 14% of all cancers in the United States, a new study suggests. Screening is currently recommended for breast, cervical, colorectal, and lung cancers by...

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